Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Department of Radiology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Oct;128(4):393-399. doi: 10.1016/j.oooo.2019.06.004. Epub 2019 Jun 14.
The aim of this study was to analyze myopericytoma in the oral and maxillofacial region in terms of clinical appearance, diagnosis, treatment, and outcomes.
Data on 5 new patients with myopericytoma in the oral and maxillofacial region treated at our department were collected and analyzed.
There were 2 males and 3 females (age range 10-62 years; mean age 43.8 years). All of the 5 patients presented with masses showing benign biologic behavior. Imaging examinations with use of computed tomography or magnetic resonance imaging showed heterogeneous regions with internal contrast-enhancement or cystic change in 3 cases. All of the patients underwent surgery. Histologic examination showed a broad morphologic spectrum characterized by concentric and perivascular growth of ovoid, plump spindled, and/or round myoid tumor cells. Immunohistochemical examination showed positive staining for vimentin and smooth muscle actin, and negative for CD34 and desmin. During the follow-up period (8-56 months), there was no tumor recurrence.
Myopericytoma in the oral and maxillofacial region always exhibits benign biologic behavior and a heterogeneous region with internal contrast-enhancement or cystic change on imaging examinations. Surgery is the first choice of treatment and results in good clinical outcomes.
本研究旨在分析口腔颌面部肌纤维母细胞瘤的临床表现、诊断、治疗和预后。
收集并分析了我科 5 例口腔颌面部肌纤维母细胞瘤新患者的数据。
2 例男性，3 例女性（年龄 10-62 岁；平均年龄 43.8 岁）。5 例患者均表现为良性生物学行为的肿块。3 例患者行 CT 或 MRI 检查显示混杂有内部增强或囊性改变的不均匀区域。所有患者均接受了手术治疗。组织学检查显示出一种广泛的形态学特征，表现为同心性和血管周围生长的卵圆形、饱满梭形和/或圆形肌样肿瘤细胞。免疫组织化学检查显示波形蛋白和平滑肌肌动蛋白阳性，CD34 和结蛋白阴性。随访 8-56 个月，未见肿瘤复发。
口腔颌面部肌纤维母细胞瘤始终表现出良性生物学行为和影像学检查显示内部增强或囊性改变的不均匀区域。手术是首选治疗方法，临床疗效良好。
