School of Health Sciences, University of Southampton, Southampton, UK.
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
BMJ Open. 2019 Jul 26;9(7):e029662. doi: 10.1136/bmjopen-2019-029662.
Understanding the impact of cancer and its treatment on people's everyday lives will help prepare people for what to expect, enable health professionals to predict likely recovery trajectories and shape care management according to needs. HORIZONS will recruit people awaiting treatment and follow them up at regular intervals to assess recovery of health and well-being.
What impact does cancer diagnosis and treatment have on people's lives in the short, medium and long term? What are people's health and well-being outcomes, experiences and self-management activities over time across different cancer types and what influences these? How do people connect with and relate to others in mobilising resources that enable them to self-manage the consequences of cancer and treatment?
HORIZONS is a multicentre, prospective cohort study exploring recovery of health and well-being in 3000 people diagnosed with breast cancer (<50 years), non-Hodgkin's lymphoma or gynaecological cancer. Recruitment will take place across National Health Service (NHS) sites in the UK between September 2016 and March 2019, before primary treatment starts. Participants will be identified through clinical teams and invited to complete questionnaires including assessments of quality of life, symptoms and functioning (Quality of Life in Adult Cancer Survivors; European Organisation for Research and Treatment Consortium Core quality of life questionnaire, EORTC-QLQ-C30), health status (EuroQol-5 dimensions, EQ-5D), self-efficacy, social support, social networks and lifestyle. Clinical data will also be collected. Descriptive statistics will characterise outcomes. Changes over time will be investigated. Factors that may influence recovery and self-management will be included in regression models to determine which influence health and well-being and self-management.
Ethics and Health Research Authority approvals granted (IRAS Project ID: 202342, REC reference number 16/NW/0425). Adopted onto the National Institute for Health Research Clinical Research Network portfolio. We will engage with our Scientific Advisory Board, Tumour Specific Expert Panels, User Reference Group, Macmillan and the University of Southampton to ensure maximum publicity and benefit.
了解癌症及其治疗对人们日常生活的影响将有助于人们做好准备，使卫生专业人员能够预测可能的康复轨迹，并根据需要塑造护理管理。HORIZONS 将招募等待治疗的患者，并定期对其进行随访，以评估健康和幸福感的恢复情况。
癌症诊断和治疗在短期、中期和长期内对人们的生活有什么影响？不同类型的癌症在不同时间内，人们的健康和幸福感结果、经历和自我管理活动是什么，以及哪些因素影响了这些结果？人们如何与他人联系并建立关系，以调动资源，使他们能够自我管理癌症和治疗的后果？
HORIZONS 是一项多中心、前瞻性队列研究，旨在探索 3000 名乳腺癌（<50 岁）、非霍奇金淋巴瘤或妇科癌症患者的健康和幸福感的恢复情况。2016 年 9 月至 2019 年 3 月期间，在开始主要治疗之前，将在英国国民保健署（NHS）的多个站点招募参与者。参与者将通过临床团队确定，并邀请他们完成问卷调查，包括生活质量、症状和功能评估（成人癌症幸存者生活质量；欧洲癌症研究与治疗组织核心生活质量问卷，EORTC-QLQ-C30）、健康状况（欧洲五维健康量表，EQ-5D）、自我效能感、社会支持、社交网络和生活方式。还将收集临床数据。描述性统计将描述结果。将研究随时间的变化。将在回归模型中纳入可能影响恢复和自我管理的因素，以确定哪些因素影响健康和幸福感以及自我管理。
伦理和健康研究管理局批准（IRAS 项目 ID：202342，REC 参考号 16/NW/0425）。被纳入国家卫生研究院临床研究网络组合。我们将与我们的科学咨询委员会、肿瘤特定专家小组、用户参考小组、麦克米伦和南安普顿大学合作，以确保最大程度的宣传和受益。
