Gromov A V, Bartov M S, Orlova P A, Manskikh V N, Krivozubov M S, Grunina T M, Manukhina M S, Strukova N V, Nikitin K E, Lunin V G, Karyagina A S, Gintsburg A L
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2019 Jul;167(3):408-412. doi: 10.1007/s10517-019-04538-5. Epub 2019 Jul 26.
Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved quantitative and qualitative characteristics of the bone tissue in the site of implantation when used in combination with BMP-2 in both concentrations.
