Molokotina Yu D, Boldyreva М А, Stafeev I S, Semina E V, Shevchenko E K, Zubkova E S, Beloglazova I B, Parfenova E V
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2019 Jul;167(3):413-417. doi: 10.1007/s10517-019-04539-4. Epub 2019 Jul 26.
A stimulating effect of a combination of hepatocyte growth factor (HGF) and glial neurotrophic factor (GDNF) on the growth of neurites in the spinal ganglion model was demonstrated. The mechanism of neurite growth in the spinal ganglion model is associated with transactivation of HGF c-met receptor in the presence of both HGF and GDNF. The combination of HGF and GDNF significantly activated mitogenic signaling cascade mediated by protein kinases ERK1/2, which can be a mechanism for increasing the number of neurites. Our findings can be used for developing effective methods for restoring impaired peripheral nerve function after traumatic and ischemic injury using a combination of GDNF and HGF.
肝细胞生长因子（HGF）和胶质神经营养因子（GDNF）的组合对脊髓神经节模型中神经突的生长具有刺激作用。脊髓神经节模型中神经突生长的机制与在HGF和GDNF同时存在时HGF c-met受体的反式激活有关。HGF和GDNF的组合显著激活了由蛋白激酶ERK1/2介导的有丝分裂信号级联反应，这可能是神经突数量增加的一种机制。我们的研究结果可用于开发有效的方法，利用GDNF和HGF的组合来恢复创伤性和缺血性损伤后受损的周围神经功能。
