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中国家庭能源包对血压、中心血液动力学和动脉僵硬的纵向评估。

Longitudinal evaluation of a household energy package on blood pressure, central hemodynamics, and arterial stiffness in China.

机构信息

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada; Institute for Health and Social Policy, McGill University, Montreal, Canada.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada.

出版信息

Environ Res. 2019 Oct;177:108592. doi: 10.1016/j.envres.2019.108592. Epub 2019 Jul 18.

Abstract

BACKGROUND

Cardiovascular diseases are the leading contributors to disease burden in China and globally, and household air pollution exposure is associated with risk of cardiovascular disease.

OBJECTIVES

We evaluated whether subclinical cardiovascular outcomes in adult Chinese women would improve after distribution of an energy package comprised of a semi-gasifier cookstove, water heater, chimney, and supply of processed biomass fuel.

METHODS

We enrolled 204 households (n = 205 women) from 12 villages into a controlled before- and after-intervention study on cardiovascular health and air pollution in Sichuan Province. The intervention was distributed to 124 households during a government-sponsored rural energy demonstration program. The remaining 80 households received the package 18 months later at the end of the study, forming a comparison group. One woman from each household had their blood pressure (BP), central hemodynamics, and arterial stiffness measured along with exposures to air pollution and demographic and household characteristics, on up to five visits. We used a difference-in-differences mixed-effects regression approach with Bayesian inference to assess the impact of the energy package on sub-clinical cardiovascular outcomes.

RESULTS

Women who did not receive the energy package had greater mean decreases in brachial systolic (-4.1 mmHg, 95% credible interval (95%CI) -7.3, -0.9) and diastolic BP (-2.0 mmHg, 95%CI -3.6, -0.5) compared with women who received the package (systolic: -2.7, 95%CI -5.0, -0.4; diastolic: -0.3, 95%CI -1.4, 0.8) resulting in slightly positive but not statistically significant difference-in-differences effect estimates of 1.3 mmHg (95%CI -2.5, 5.2) and 1.7 mmHg (95%CI -0.3, 3.6), respectively. Similar trends were found for central BP, central pulse pressure, and arterial stiffness. Air pollution exposures decreased on average for both treatment groups, with a greater range of reductions among women who did not receive the package (with package: -30% to -50%; without package: +2% to -69%), likely as a result of increased use of gas fuel and electric stoves among this group. Outdoor air quality changed very little over time.

CONCLUSIONS

Gasifier stoves have been widely promoted as the next generation of 'clean-cooking' technologies, however their effectiveness in improving health in real-world settings should be carefully evaluated and communicated before scaling up their implementation.

摘要

背景

心血管疾病是中国和全球疾病负担的主要原因,家庭空气污染暴露与心血管疾病风险相关。

目的

我们评估了在中国成年女性中,分配包含半气化炉、热水器、烟囱和加工生物质燃料供应的能源包是否会改善亚临床心血管结局。

方法

我们在四川省开展了一项关于心血管健康和空气污染的对照前后干预研究,共招募了 12 个村庄的 204 户家庭(n=205 名女性)。干预措施在政府主办的农村能源示范项目中分配给 124 户家庭。其余 80 户家庭在研究结束时(即 18 个月后)作为对照组获得了该能源包。每户家庭中有一位女性接受了血压(BP)、中心血液动力学和动脉僵硬的测量,同时还测量了空气污染暴露情况以及人口统计学和家庭特征,最多进行了五次访问。我们使用贝叶斯推断的差异-差异混合效应回归方法来评估能源包对亚临床心血管结局的影响。

结果

未获得能源包的女性收缩压(-4.1mmHg,95%可信区间(95%CI)-7.3,-0.9)和舒张压(-2.0mmHg,95%CI -3.6,-0.5)的平均下降幅度大于获得能源包的女性(收缩压:-2.7mmHg,95%CI -5.0,-0.4;舒张压:-0.3mmHg,95%CI -1.4,0.8),导致差异-差异效应估计值略呈阳性但无统计学意义,分别为 1.3mmHg(95%CI -2.5,5.2)和 1.7mmHg(95%CI -0.3,3.6)。中心血压、中心脉搏压和动脉僵硬也出现了类似的趋势。两组的空气污染暴露平均均有所下降,未获得能源包的女性下降幅度更大(获得能源包:-30%至-50%;未获得能源包:+2%至-69%),可能是由于该组更多地使用燃气燃料和电炉。室外空气质量在一段时间内变化很小。

结论

气化炉已被广泛推广为下一代“清洁烹饪”技术,但其在实际环境中改善健康的效果应在扩大其实施之前进行仔细评估和沟通。

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