Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
EBioMedicine. 2019 Aug;46:532-540. doi: 10.1016/j.ebiom.2019.07.051. Epub 2019 Jul 24.
Chronic heart failure (CHF) has long been a major medical care burden on society due to its high morbidity and mortality. Although lots of evidence has demonstrated the beneficial impacts of exercise on CHF, termed exercise-induced cardioprotection (EIC), the underlying mechanisms and applicability of EIC are elusive and controversial, and thus, clinical applications are difficult. Noncoding RNAs (ncRNAs) are potential therapeutic targets for CHF. Increasing number of ncRNAs were found to play a role in EIC and CHF. The purpose of this review is to illustrate the current knowledge of ncRNAs in EIC for CHF as well as their prospective and limitations in clinical application.
慢性心力衰竭（CHF）由于其高发病率和死亡率，长期以来一直是社会的主要医疗负担。尽管大量证据表明运动对 CHF 有益，即运动诱导的心肌保护（EIC），但其潜在机制和适用性仍难以捉摸且存在争议，因此临床应用困难。非编码 RNA（ncRNA）是 CHF 的潜在治疗靶点。越来越多的 ncRNA 被发现在 EIC 和 CHF 中发挥作用。本综述的目的是阐述 ncRNA 在 EIC 治疗 CHF 中的最新知识，以及它们在临床应用中的前景和局限性。
