Joint International Research Laboratory of Glycobiology and Medicinal Chemistry, College of Life Sciences, Northwest University, Xi'an, China; Department of Oncology, the Fifth People's Hospital of Qinghai Province, Xining, China.
Joint International Research Laboratory of Glycobiology and Medicinal Chemistry, College of Life Sciences, Northwest University, Xi'an, China.
Cell Signal. 2019 Nov;63:109365. doi: 10.1016/j.cellsig.2019.109365. Epub 2019 Jul 25.
Reduced cellular adhesiveness as a result of cadherin dysfunction is a defining feature of cancer and the mechanism involved in many aspects. Glycosylation is one of the most important post-translational modifications to cadherin. Major changes of glycosylation on cadherins can affect its stability, trafficking, and cell-adhesion properties. It has been reported that the different glycoforms of cadherins are promising biomarkers in cancer, with potential clinical application to constitute targets for the development of new therapies. Among the various glycoforms of cadherins, fucosylated and O-glycosylated cadherins are attracting more attention for their important roles in regulating cadherin functions during carcinogenesis. This review will discuss the most recent insights of the functional roles of fucosylated and O-glycosylated cadherins and their regulation mechanisms during carcinogenesis and metastasis. In summary, more understanding of fucosylated and O-glycosylated cadherins will lead to development of novel therapeutic approaches targeted to cancer.
细胞黏附性降低是肿瘤的一个重要特征，也是涉及多个方面的机制，而这主要是由于黏附蛋白功能障碍所致。糖基化是黏附蛋白最重要的翻译后修饰之一。黏附蛋白糖基化的主要变化会影响其稳定性、运输和细胞黏附特性。已有报道称，黏附蛋白的不同糖型有望成为癌症的生物标志物，具有潜在的临床应用价值，可作为开发新疗法的靶点。在黏附蛋白的各种糖型中，岩藻糖基化和 O-糖基化黏附蛋白因其在肿瘤发生过程中调节黏附蛋白功能方面的重要作用而受到更多关注。本文将讨论岩藻糖基化和 O-糖基化黏附蛋白在肿瘤发生和转移过程中的功能作用及其调控机制的最新研究进展。总之，对岩藻糖基化和 O-糖基化黏附蛋白的进一步了解将有助于开发针对癌症的新型治疗方法。
