Erukainure Ochuko L, Oyebode Olajumoke A, Chukwuma Chika I, Matsabisa Motlalepula G, Koorbanally Neil A, Islam Md Shahidul
Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban, South Africa.
Nutrition and Toxicology Division, Federal Institute of Industrial Research, Lagos, Nigeria.
J Food Biochem. 2019 Mar;43(3):e12749. doi: 10.1111/jfbc.12749. Epub 2018 Dec 17.
Raffia palm wine is a natural drink from the stem of Raffia palm (Raphia hookeri) tree with nutritional and medicinal properties. The effect of fermentation was investigated on its antidiabetic and antioxidative effects in yeast cells and pancreatic tissues, respectively. Both unfermented and fermented palm wine significantly increased glucose uptake, reduced glutathione level (GSH), superoxide dismutase, and catalase activities. They also inhibited glucose diffusion, myeloperoxidase, and ATPase activities as well as decreased malondialdehyde and nitric oxide levels. They also led to the inactivation of oxidative metabolic pathways in oxidative pancreas with the generation of adenosine, sugar and inositol metabolites, selenium (enzyme co-factor) and vitamin metabolites owing to concomitant activation of vitamins, lipid, steroids, inositol, and sulfate/sulfite metabolic pathways. The results suggest the antidiabetic and antioxidative potentials of unfermented and fermented palm wine and may be attributed to the LC-MS-identified compounds which were mainly polyphenols and its glycosides, vitamins, and amino acids. PRACTICAL APPLICATIONS: Raffia palm wine is among the natural beverages employed for social, nutritional, and medicinal purposes. However, there are limited studies on its medicinal properties. This study reports for the first time, the ability of Raffia palm wine to stimulate glucose uptake, inhibit glucose diffusion, and ameliorate pancreatic oxidative injury, as well as the possible associated metabolic pathways that may be involved. These findings will further contribute in understanding the antidiabetic effect of Raffia palm wine, and the possible metabolic pathways involved.
酒椰棕榈酒是一种源自酒椰棕榈（Raphia hookeri）树茎的天然饮品，具有营养和药用特性。分别研究了发酵对其在酵母细胞和胰腺组织中的抗糖尿病和抗氧化作用的影响。未发酵和发酵的棕榈酒均能显著增加葡萄糖摄取、降低谷胱甘肽水平（GSH）、超氧化物歧化酶和过氧化氢酶活性。它们还抑制葡萄糖扩散、髓过氧化物酶和ATP酶活性，并降低丙二醛和一氧化氮水平。它们还导致氧化胰腺中氧化代谢途径失活，同时激活维生素、脂质、类固醇、肌醇和硫酸盐/亚硫酸盐代谢途径，从而产生腺苷、糖类和肌醇代谢物、硒（酶辅因子）和维生素代谢物。结果表明未发酵和发酵的棕榈酒具有抗糖尿病和抗氧化潜力，这可能归因于经液相色谱-质谱联用鉴定的化合物，主要是多酚及其糖苷、维生素和氨基酸。实际应用：酒椰棕榈酒是用于社交、营养和药用目的的天然饮品之一。然而，关于其药用特性的研究有限。本研究首次报道了酒椰棕榈酒刺激葡萄糖摄取、抑制葡萄糖扩散和改善胰腺氧化损伤的能力，以及可能涉及的相关代谢途径。这些发现将进一步有助于理解酒椰棕榈酒的抗糖尿病作用以及可能涉及的代谢途径。
