Kalogeropoulos Dimitrios, Sung Velota Ct
Birmingham and Midland Eye Centre, Sandwell and West Birmingham Hospital, NHS Trust, UK.
J Curr Glaucoma Pract. 2018 Sep-Dec;12(3):125-138. doi: 10.5005/jp-journals-10028-1257.
Uveitic glaucoma consists one of the most serious complications of intraocular inflammation and, despite its rarity, is considered as one of the leading causes of preventable loss of vision worldwide. It has been associated with a wide spectrum of inflammatory diseases, but its pathogenesis is still not fully comprehended. It appears that the type of inflammation, the steroid-response and the anatomical alterations of the anterior chamber play a pivotal role. To our knowledge, the mechanisms may be both acute and chronic. The main targets of the treatment are to control the inflammation and reduce the intraocular pressure (IOP). The management of glaucoma associated with uveitis remains an extremely challenging condition for ophthalmologists. The successful treatment of uveitic glaucoma is inextricably correlated with prompt and immediate therapeutic decisions. Very often a solid collaboration between clinicians from different specialties may be required for treating the underlying disease. Further understanding of its pathogenesis can indicate therapeutic targets and may lead to the development of new and more efficient therapeutic approaches. New glaucoma surgical modalities may ameliorate the prognosis after surgical intervention, but this calls for further evaluation. This study aims to highlight the complexity of uveitic glaucoma analyzing the main pathogenetic mechanisms and the correlations with the inflammatory response.
Kalogeropoulos D, Sung VCT. Pathogenesis of Uveitic Glaucoma. J Curr Glaucoma Pract 2018;12(3):125-138.
葡萄膜炎性青光眼是眼内炎症最严重的并发症之一，尽管其罕见，但被认为是全球可预防视力丧失的主要原因之一。它与多种炎症性疾病相关，但其发病机制仍未完全明了。似乎炎症类型、类固醇反应和前房的解剖改变起关键作用。据我们所知，其机制可能既有急性的也有慢性的。治疗的主要目标是控制炎症和降低眼压（IOP）。葡萄膜炎相关性青光眼的治疗对眼科医生来说仍然是极具挑战性的情况。葡萄膜炎性青光眼的成功治疗与迅速即时的治疗决策密切相关。治疗潜在疾病时，不同专科的临床医生之间常常需要紧密合作。对其发病机制的进一步了解可以指明治疗靶点，并可能导致新的、更有效的治疗方法的发展。新的青光眼手术方式可能改善手术干预后的预后，但这需要进一步评估。本研究旨在通过分析主要发病机制以及与炎症反应的相关性，突出葡萄膜炎性青光眼的复杂性。
卡洛耶罗普洛斯D，宋VCT。葡萄膜炎性青光眼的发病机制。《当代青光眼实践杂志》2018；12(3)：125 - 138。
