Halkiadakis Ioannis, Konstantopoulou Kalliroi, Tzimis Vasilios, Papadopoulos Nikolaos, Chatzistefanou Klio, Markomichelakis Nikolaos N
Ophthalmiatrion Athinon, Athens Eye Hospital, 10672 Athens, Greece.
First Department of Ophthalmology, National and Kapodistrian University of Athens School of Medicine, Athens General Hospital "G. Gennimatas", 11527 Athenbs, Greece.
J Clin Med. 2024 Feb 20;13(5):1185. doi: 10.3390/jcm13051185.
Glaucoma is a common and potentially blinding complication of uveitis. Many mechanisms are involved alone or in combination in the pathogenesis of uveitic glaucoma (UG). In terms of diagnostic evaluation, the effects of inflammatory activity in the retinal nerve fiber layer may be a source of bias in the interpretation of optical coherence tomography measurements. For the successful treatment of UG, the control of intraocular inflammation specific to the cause or anti-inflammatory treatment, combined with IOP management, is mandatory. The early institution of specific treatment improves the prognosis of UG associated with CMV. The young age of UG patients along with increased failure rates of glaucoma surgery in this group of patients warrants a stepwise approach. Conservative and conjunctival sparing surgical approaches should be adopted. Minimally invasive surgical approaches were proved to be effective and are increasingly being used in the management of UG along with the traditionally used techniques of trabeculectomy or tubes. This review aims to summarize the progress that recently occurred in the diagnosis and treatment of UG.
青光眼是葡萄膜炎常见且可能致盲的并发症。葡萄膜炎性青光眼(UG)的发病机制涉及多种单独或联合作用的机制。在诊断评估方面,视网膜神经纤维层炎症活动的影响可能是光学相干断层扫描测量结果解读中偏差的一个来源。为成功治疗UG,针对病因控制眼内炎症或进行抗炎治疗,并结合眼压管理是必不可少的。早期进行特异性治疗可改善与巨细胞病毒相关的UG的预后。UG患者较为年轻,且该组患者青光眼手术失败率增加,因此需要采取循序渐进的方法。应采用保守且保留结膜的手术方法。事实证明,微创外科手术方法是有效的,并且与传统的小梁切除术或引流管植入术等技术一起,越来越多地用于UG的治疗。本综述旨在总结UG诊断和治疗方面最近取得的进展。