Hattori H, Mikuriya S, Mamiya T, Hatano K, Shiina T, Yamada T
Dept. of Radiology, National Medical Center Hospital.
Gan No Rinsho. 1988 Jun;34(7):851-6.
Fourty-three patients with pleuritis carcinomatosa have been treated with an intra-thoracic administration in four distinct ways: Adriamycin alone, OK-432 alone, the combination of Adriamycin with OK-432, or the combination of Mitomycin C with OK-432. Judging from an evaluation of the subsequent chest X-rays, the prognosis of the cases which received the combination therapy of the two drugs was significantly better to that of the others. There were no significant differences between cases with primary lung cancer and those with other cancers. As for the side effects after the administration, there were no side effects, such as the trouble the renal function or liver function, other than fever and a decrease in the W.B.C.
43例癌性胸膜炎患者接受了四种不同方式的胸腔内给药治疗：单独使用阿霉素、单独使用OK-432、阿霉素与OK-432联合使用、丝裂霉素C与OK-432联合使用。从随后胸部X光片的评估来看，接受两种药物联合治疗的病例预后明显优于其他病例。原发性肺癌患者和其他癌症患者之间没有显著差异。关于给药后的副作用，除了发热和白细胞减少外，没有出现诸如肾功能或肝功能问题等副作用。
