Fan Xuehui, Sun Tianyi, Crawford William, Tan Xiaoqiu, Ou Xianhong, Terrar Derek A, Ebert Steven N, Lei Ming
Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Front Physiol. 2019 Jul 10;10:713. doi: 10.3389/fphys.2019.00713. eCollection 2019.
In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca transient properties, and potential role in localized adrenergic signaling are discussed.
在本综述中，我们概述了苯乙醇胺 - N - 甲基转移酶（Pnmt）衍生的心肌细胞（PdCMs），这是最近发现的一种心肌细胞亚群。我们讨论了它们的解剖定位、生理特征、可能的功能以及未来展望。文中探讨了它们在心脏中的独特分布、电活动、钙瞬变特性以及在局部肾上腺素能信号传导中的潜在作用。
