帕金森病的“开-关”现象：血浆中多巴与其他大中性氨基酸的关系
'On-off' phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma.
作者信息
Eriksson T, Granérus A K, Linde A, Carlsson A
机构信息
Department of Pharmacology, University of Göteborg, Sweden.
出版信息
Neurology. 1988 Aug;38(8):1245-8. doi: 10.1212/wnl.38.8.1245.
PMID:3135513
Abstract
Administration of a low-protein diet to parkinsonian patients with "on-off" syndromes consistently increased the total daily time of "on" states when compared with a high-protein diet. The clinical effect of the low-protein diet may be due to a marked decrease in the plasma concentration of large neutral amino acids that compete with L-dopa for carrier-mediated transport into the brain.
摘要
与高蛋白饮食相比，给患有“开-关”综合征的帕金森病患者采用低蛋白饮食，持续增加了每日“开”状态的总时长。低蛋白饮食的临床效果可能是由于血浆中大中性氨基酸的浓度显著降低，这些氨基酸会与左旋多巴竞争通过载体介导转运进入大脑。
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