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评价伴有和不伴有牙槽嵴保存的磨牙拔牙位点的愈合:一项三臂组织学分析。

Evaluation of healing at molar extraction sites with and without ridge preservation: A three-arm histologic analysis.

机构信息

Department of Periodontics, UT Health San Antonio, San Antonio, TX.

Department of Pathology, UT Health San Antonio, San Antonio, TX.

出版信息

J Periodontol. 2020 Jan;91(1):74-82. doi: 10.1002/JPER.19-0237. Epub 2019 Aug 11.

Abstract

BACKGROUND

Little evidence is available regarding the benefit of ridge preservation (RP) at molar sites. The primary objective of this three-arm cohort study was to histologically compare the healing outcome between natural healing after molar tooth extraction and two different techniques of RP using freeze-dried bone allograft (FDBA) and a nonresorbable dense polytetrafluoroethylene (dPTFE) membrane, or an absorbable collagen sponge as a barrier.

METHODS

Seventy-nine patients requiring extraction and delayed implant placement were placed into three groups: extraction alone (control); ridge preserved using FDBA; and either dPTFE (Test1) or collagen sponge (Test2). Bone cores were harvested from implant osteotomies at ≈3 months after extraction for histomorphometric analysis to determine the percentage of vital bone, residual graft, and connective or other tissue. Ridge dimension changes were also evaluated radiographically (cone-beam computed tomography).

RESULTS

The percentage of vital bone was significantly greater in control group compared with Test1 but was not statistically different among other groups. Test2 showed significantly less connective or other tissue than control and Test1. The percentage of residual graft was significantly lower in Test1 compared with Test2. There was no significant correlation between the percentage of vital bone or residual graft and the following parameters: healing time, patient age, gender, buccal plate thickness, or radiographic changes in ridge dimensions.

CONCLUSION

RP at molar sites using FDBA and an absorbable collagen sponge may be a sufficient and economic way to preserve the ridge dimension without interfering with the amount of new bone formation.

摘要

背景

关于磨牙部位嵴顶保存(RP)的益处,目前仅有很少的证据。本三臂队列研究的主要目的是通过组织学比较磨牙拔牙后自然愈合与使用冻干骨移植物(FDBA)和不可吸收致密聚四氟乙烯(dPTFE)膜或可吸收胶原海绵作为屏障的两种不同 RP 技术之间的愈合结果。

方法

79 名需要拔牙和延迟种植的患者被分为三组:单纯拔牙(对照组);使用 FDBA 进行嵴顶保存;以及使用 dPTFE(Test1)或胶原海绵(Test2)。拔牙后约 3 个月,从种植体骨切开术中取出骨芯进行组织形态计量学分析,以确定活骨、残留移植物和结缔组织或其他组织的百分比。还通过放射影像学(锥形束计算机断层扫描)评估牙槽嵴的尺寸变化。

结果

与 Test1 相比,对照组的活骨百分比显著更高,但与其他组之间无统计学差异。Test2 显示的结缔组织或其他组织明显少于对照组和 Test1。Test1 中的残留移植物百分比明显低于 Test2。活骨或残留移植物的百分比与以下参数之间无显著相关性:愈合时间、患者年龄、性别、颊侧骨板厚度或牙槽嵴尺寸的放射影像学变化。

结论

在磨牙部位使用 FDBA 和可吸收胶原海绵进行 RP 可能是一种充分且经济的方法,可以在不干扰新骨形成量的情况下保存牙槽嵴的尺寸。

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