Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
J Surg Oncol. 2019 Oct;120(5):864-872. doi: 10.1002/jso.25645. Epub 2019 Jul 29.
In the era of advanced cancer genomics, our recognition of hereditary cancer mutations continues to increase. Two of these conditions, which carry an increased risk of female cancers including endometrial, ovarian, breast, are hereditary breast and ovarian cancer syndrome and Lynch syndrome. Risk-reducing surgery, such as mastectomy, salpingo-oophorectomy, and hysterectomy may decrease cancer risk for mutation carriers. Background, indications, techniques, and consequences of these surgical procedures are reviewed.
在癌症基因组学的时代，我们对遗传性癌症突变的认识不断增加。其中两种情况会增加女性患癌症的风险，包括子宫内膜癌、卵巢癌、乳腺癌，即遗传性乳腺癌和卵巢癌综合征以及林奇综合征。对于突变携带者，预防性手术，如乳房切除术、输卵管卵巢切除术和子宫切除术，可能会降低癌症风险。本文回顾了这些手术的背景、适应证、技术和后果。
