Xenophontos Soteris, Wilkinson Thomas J, Gould Douglas W, Watson Emma L, Viana João L, Smith Alice C
Department of Infection Immunity and Inflammation, University of Leicester, Leicester, UK.
Leicester Kidney Lifestyle Team, Department of Health Sciences, University of Leicester, Leicester, UK.
J Ren Care. 2019 Sep;45(3):185-192. doi: 10.1111/jorc.12293. Epub 2019 Jul 29.
Assessment of cardiorespiratory fitness is an important outcome in chronic kidney disease (CKD). We aimed to develop a predictive equation to estimate peak oxygen uptake (VO ) and power output (W ), as measured during a cardiopulmonary exercise test (CPET), from the distance walked (DW) during the incremental shuttle walk test (ISWT).
Thirty-six non-dialysing patients with CKD [17 male, age: 61 ± 12 years, eGFR: 25±7 ml/min/1.73 m , body mass index (BMI): 31 ± 6 kg/m ] carried out laboratory-based CPET on a cycle ergometer and ISWT on two separate occasions.
Linear regression revealed that DW/BMI was a significant predictor of VO (r = 0.78) (VO (ml/min/kg) = [0.5688 × (DW/BMI) (m)] + 11.50). No difference (p = 0.66) between CPET VO (19.9 ± 5.5 ml/min/kg) and predicted VO (19.9 ± 4.3 ml/min/kg) was observed. DW multiplied by body mass (BM) was a significant predictor of W (r = 0.80) [W (W) = (0.0018 × (DW × BM)) + 50.47]. No difference (p = 0.97) between CPET W (116.2 ± 38.9 W) and estimated W (113.9 ± 30.1 W) was seen.
The present study demonstrates that VO and W can be accurately estimated using the DW during an ISWT in CKD populations.
评估心肺适能是慢性肾脏病（CKD）的一项重要指标。我们旨在建立一个预测方程，根据递增往返步行试验（ISWT）中的步行距离（DW）来估算心肺运动试验（CPET）中测得的峰值摄氧量（VO ）和功率输出（W ）。
36例非透析CKD患者[17例男性，年龄：61±12岁，估算肾小球滤过率（eGFR）：25±7ml/min/1.73m ，体重指数（BMI）：31±6kg/m ]在两个不同时间分别进行了基于实验室的蹬车式CPET和ISWT。
线性回归显示，DW/BMI是VO 的显著预测因子（r = 0.78）（VO （ml/min/kg）= [0.5688×（DW/BMI）（m）]+11.50）。观察到CPET测得的VO （19.9±5.5ml/min/kg）与预测的VO （19.9±4.3ml/min/kg）之间无差异（p = 0.66）。DW乘以体重（BM）是W 的显著预测因子（r = 0.80）[W （W）=（0.0018×（DW×BM））+50.47]。CPET测得的W （116.2±38.9W）与估算的W （113.9±30.1W）之间无差异（p = 0.97）。
本研究表明，在CKD人群中，使用ISWT中的DW可以准确估算VO 和W 。
