受孕时的父母年龄及其与自闭症症状严重程度的关系。
Parental Age at Conception and the Relationship with Severity of Autism Symptoms.
作者信息
Rieske Robert D, Matson Johnny L
机构信息
Idaho State University , Pocatello, ID, USA.
Louisiana State University , Baton Rouge, LA, USA.
出版信息
Dev Neurorehabil. 2020 Jul;23(5):265-270. doi: 10.1080/17518423.2019.1645222. Epub 2019 Jul 29.
BACKGROUND
Previous research has examined the relationship between advanced parental age at conception and the incidence of autism, and has noted strong relationships between advanced parental age and other developmental disabilities.
AIM
The purpose of this study was to confirm that and extend that knowledge to the association between advanced parental age and severity of autism symptoms as measured by a parental report of ASD symptom severity.
METHODS
The current study included 252 participants between the ages of 2-17 years and their parents.
RESULTS
Child's gender and paternal age were found to be significant predictors of autism severity with males and children with older fathers at conception showing the highest severity. Interestingly, maternal age was not found to be a significant predictor of autism risk or severity of symptoms in this sample.
CONCLUSION
Possible explanations for these findings are discussed, as well as future directions for research in this area.
背景
先前的研究探讨了受孕时父母年龄较大与自闭症发病率之间的关系，并指出父母年龄较大与其他发育障碍之间存在密切关系。
目的
本研究的目的是证实这一点，并将这一知识扩展到父母年龄较大与自闭症症状严重程度之间的关联，该关联通过父母对自闭症谱系障碍（ASD）症状严重程度的报告来衡量。
方法
本研究纳入了252名年龄在2至17岁之间的参与者及其父母。
结果
发现孩子的性别和父亲年龄是自闭症严重程度的重要预测因素，男性以及受孕时父亲年龄较大的孩子症状最为严重。有趣的是，在这个样本中，母亲年龄并未被发现是自闭症风险或症状严重程度的重要预测因素。
结论
讨论了这些发现的可能解释以及该领域未来的研究方向。
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