State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
Nanoscale. 2019 Aug 8;11(31):14654-14667. doi: 10.1039/c9nr04858h.
The limited light penetration depth and tumor hypoxia are two natural shortcomings of photodynamic therapy (PDT). Overcoming these two issues within a single system is still a great challenge. Herein, photosensitizer (PS)-loaded and PEG-modified MnFe2O4-decorated large-pore mesoporous silica-coated β-NaYF4:20%Yb,2%Er@β-NaYF4 upconversion nanoparticles (UCMnFe-PS-PEG) as excellent PDT agents are successfully prepared for NIR light-mediated and O2 self-sufficient PDT. The large mesoporous structure observably increases PS loading efficiency (11.33 wt%) and the green luminescence from upconversion nanoparticles activated by NIR is able to activate PSs to generate ROS effectively. In addition, sub-10 nm MnFe2O4 nanoparticles work as a Fenton catalyst to generate O2in situ. In vivo experiments further prove that UCMnFe-PS-PEG not only provides magnetic guidance to the tumor, but also overcomes tumor hypoxia and dramatically enhances PDT efficiency. Furthermore, in vivo MR and UCL imaging are performed for accurate cancer therapy. We believe that the successful construction of the multifunctional UCMnFe-PS-PEG provides more revelations for developing advanced nano-drug systems for cancer therapy.
有限的光穿透深度和肿瘤缺氧是光动力疗法（PDT）的两个天然缺陷。在单个系统中克服这两个问题仍然是一个巨大的挑战。在此，负载光敏剂（PS）和聚乙二醇（PEG）修饰的 MnFe2O4 修饰的大孔介孔硅包覆β-NaYF4：20%Yb，2%Er@β-NaYF4 上转换纳米粒子（UCMnFe-PS-PEG）作为优异的 PDT 剂，成功用于近红外光介导和 O2 自足 PDT。大的介孔结构显著提高 PS 负载效率（11.33wt%），并且由近红外光激活的上转换纳米粒子的绿光能够有效地激活 PS 产生 ROS。此外，亚 10nm 的 MnFe2O4 纳米粒子作为芬顿催化剂原位产生 O2。体内实验进一步证明，UCMnFe-PS-PEG 不仅为肿瘤提供了磁导向，而且克服了肿瘤缺氧并显著提高了 PDT 效率。此外，进行了体内磁共振和 UCL 成像以进行精确的癌症治疗。我们相信，多功能 UCMnFe-PS-PEG 的成功构建为开发用于癌症治疗的先进纳米药物系统提供了更多启示。
