癌症中针对癌胚基因的细胞免疫反应。
Cellular immune responses against cancer-germline genes in cancers.
作者信息
Dashti Sepideh, Taherian-Esfahani Zahra
出版信息
Hum Antibodies. 2020;28(1):57-64. doi: 10.3233/HAB-190392.
BACKGROUND
Cancer-germline genes are a class of genes that are normally expressed in testis, trophoblast and few somatic tissues but abnormally expressed in tumor tissues. Their expression signature indicates that they can induce cellular immune responses, thus being applied as targets in cancer immunotherapy.
OBJECTIVES
To obtain the data of cellular immune responses against cancer-germline genes in cancer.
METHODS
We searched PubMed/Medline with the key words cancer-germline antigen, cancer-testis antigen, CD4+ T cell, CD8+ T cell and cancer.
RESULTS
About 40 cancer-germline genes have been shown to induce T cell specific responses in cancer patients. Melanoma, lung and breast cancer are among the mostly assessed cancer types. Several epitopes have been identified which can be used in immunotherapy of cancer.
CONCLUSION
Cellular immune responses against cancer-germline genes are indicative of appropriateness of these genes as therapeutic targets.
背景
癌胚基因是一类通常在睾丸、滋养层和少数体细胞组织中表达，但在肿瘤组织中异常表达的基因。它们的表达特征表明其可诱导细胞免疫反应，因此被用作癌症免疫治疗的靶点。
目的
获取癌症中针对癌胚基因的细胞免疫反应数据。
方法
我们以癌胚抗原、癌睾丸抗原、CD4+ T细胞、CD8+ T细胞和癌症为关键词在PubMed/Medline中进行检索。
结果
约40种癌胚基因已被证明可在癌症患者中诱导T细胞特异性反应。黑色素瘤、肺癌和乳腺癌是评估最多的癌症类型。已鉴定出几种可用于癌症免疫治疗的表位。
结论
针对癌胚基因的细胞免疫反应表明这些基因作为治疗靶点的适用性。
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