Rana Divya, Pollard Leann, Rowland Jonathan, Dhanireddy Ramasubbareddy, Pourcyrous Massroor
Department of Pediatrics, Division of Neonatology, University of Tennessee Health Science Center, Memphis, TN, USA.
J Neonatal Perinatal Med. 2019;12(4):391-397. doi: 10.3233/NPM-1834.
To describe amplitude-integrated encephalogram (aEEG) characteristics of neonates with neonatal abstinence syndrome (NAS).
This is a prospective observational study. Newborns exposed to prenatal opioids and their gestational matched controls were included. A single-channel aEEG was obtained using Olympic 6000 CFM monitor. The background activity (continuous/discontinuous), the amplitudes (μV) and the presence of sleep-wake cycle (SWC) were documented.
A total of 59 infants, 23 with NAS and 36 controls were enrolled. All aEEG were completed within 48 hours of life prior to initiation of treatment. Birth weight and gestational age were similar in both groups. An aEEG was abnormal (discontinuous pattern and/or absent SWC) in 78 % (18/23) of infants with NAS versus only 25% in control group (9/36), [OR 10.8, CI (2.7-46.5) P < 0.001]. 61% of infants with NAS had discontinuous pattern [OR 7.8, CI (2-32) P = 0.001] and 39% had absence of sleep-wake cycle [OR 7.1, CI (1.4-39.4) P = 0.007].
A majority of infants with NAS have abnormal aEEG activity.
描述新生儿戒断综合征（NAS）患儿的振幅整合脑电图（aEEG）特征。
这是一项前瞻性观察性研究。纳入产前暴露于阿片类药物的新生儿及其孕周匹配的对照组。使用Olympic 6000 CFM监护仪获取单通道aEEG。记录背景活动（连续/不连续）、振幅（μV）以及睡眠-觉醒周期（SWC）情况。
共纳入59例婴儿，其中23例患有NAS，36例为对照组。所有aEEG均在开始治疗前出生后48小时内完成。两组的出生体重和孕周相似。NAS患儿中78%（18/23）的aEEG异常（不连续模式和/或无SWC），而对照组仅为25%（9/36），[比值比（OR）10.8，可信区间（CI）（2.7 - 46.5），P＜0.001]。61%的NAS患儿有不连续模式[OR 7.8，CI（2 - 32），P = 0.001]，39%无睡眠-觉醒周期[OR 7.1，CI（1.4 - 39.4），P = 0.007]。
大多数NAS患儿有异常的aEEG活动。
