Department of Otorhinolaryngology, Kanazawa Medical University, Ishikawa, Japan.
Department of Physics, Kanazawa Medical University, Ishikawa, Japan.
Int Forum Allergy Rhinol. 2019 Nov;9(11):1252-1256. doi: 10.1002/alr.22395. Epub 2019 Jul 29.
In this study, we aimed to determine whether nasal thallium-201 uptake of the olfactory cleft and olfactory bulb (OB) differs between patients with parosmia with and without hyposmia after upper respiratory tract infection (URTI).
Twenty patients with parosmia after URTI were enrolled in this study (15 women and 5 men, 28 to 76 years old). Nasally administered thallium-201 migration to the OB, nasal thallium-201 uptake ratio in the olfactory cleft, and OB volume were determined in 10 patients with normal T&T olfactometry (Daiichi Yakuhin Sangyo, Tokyo, Japan) odor recognition thresholds (≤2.0) who still complained of parosmia (parosmia group), and 10 patients with T&T odor recognition thresholds >2.0 (parosmia and hyposmia group).
The nasal thallium-201 uptake ratio in the olfactory cleft was significantly higher in the parosmia group than in the parosmia and hyposmia group (p = 0.0015). Thallium-201 migration to the OB was not significantly different between the 2 groups (p = 0.31). The OB volume was significantly larger in the parosmia group than that in the parosmia and hyposmia group (p = 0.029); however, the mean OB volume in both the groups was lower than the normal threshold value in healthy individuals.
Our results signify the recovery of the olfactory epithelium; however, the olfactory neural projections to the OB and regeneration of OB were not complete in patients with parosmia with normal T&T recognition thresholds after URTI.
本研究旨在确定上呼吸道感染（URTI）后伴或不伴嗅觉减退的幻嗅患者的嗅裂和嗅球（OB）摄取的鼻内铊-201 是否存在差异。
本研究纳入了 20 例 URTI 后出现幻嗅的患者（15 名女性，5 名男性，年龄 28 至 76 岁）。10 例 T&T 嗅觉识别阈值（≤2.0）仍有幻嗅的患者（幻嗅组）和 10 例 T&T 嗅觉识别阈值>2.0 的患者（幻嗅和嗅觉减退组）接受了鼻内铊-201 向 OB 的迁移、嗅裂内的鼻内铊-201 摄取比和 OB 体积的测定。
嗅裂内的鼻内铊-201 摄取比在幻嗅组明显高于幻嗅和嗅觉减退组（p = 0.0015）。两组间 OB 摄取的差异无统计学意义（p = 0.31）。幻嗅组的 OB 体积明显大于幻嗅和嗅觉减退组（p = 0.029）；然而，两组的平均 OB 体积均低于健康个体的正常阈值。
我们的结果表明嗅觉上皮已经恢复；然而，在 URTI 后 T&T 识别阈值正常的幻嗅患者中，嗅神经向 OB 的投射和 OB 的再生并未完全恢复。
