Department of Otorhinolaryngology-Head and Neck Surgery, Kanazawa Medical University, Kahokugun, Ishikawa, Japan.
Mol Imaging Biol. 2011 Dec;13(6):1262-6. doi: 10.1007/s11307-010-0461-3.
The aim of this study was to visualize the human olfactory transport pathway to the brain by performing imaging after nasal thallium-201 ((201)Tl) administration.
Healthy volunteers were enrolled in this study after giving informed consent (five males, 35-51 years old). The subjects were nasally administered (201)TlCl into either the olfactory cleft. Twenty-four hours later, uptake of (201)Tl was detected by a single photon emission computed tomography (SPECT)/X-ray computed tomography hybrid system. For each subject, an MRI image was obtained and merged with the SPECT image.
The peak of the (201)Tl uptake entered into the olfactory bulb in the anterior skull base through the cribriform lamina 24 h after nasal administration of (201)Tl. No participant had olfactory disturbance after treatment.
Nasal (201)Tl administration was safely used to assess the direct pathway to the brain via the nose in healthy volunteers with normal olfactory threshold.
本研究旨在通过对鼻腔给予铊-201（201Tl）后的成像，可视化人类嗅探器向大脑的传输途径。
在知情同意后，本研究招募了健康志愿者（五名男性，年龄 35-51 岁）。将 201TlCl 通过鼻腔给予研究对象至嗅裂。24 小时后，使用单光子发射计算机断层扫描（SPECT）/X 射线计算机断层扫描混合系统检测 201Tl 的摄取。对于每个研究对象，都获得了 MRI 图像并与 SPECT 图像融合。
在鼻腔给予 201Tl 后的 24 小时，（201）Tl 的摄取峰值通过筛板进入前颅底的嗅球。治疗后，没有参与者出现嗅觉障碍。
在嗅觉阈值正常的健康志愿者中，经鼻给予 201Tl 是一种安全的方法，可用于评估通过鼻子向大脑的直接途径。
