Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan.
Int J Mol Sci. 2019 Jul 26;20(15):3660. doi: 10.3390/ijms20153660.
Sugar acids obtained by aldohexose oxidation of both the terminal aldehyde group and the hydroxy group at the other end to carboxyl groups are called hexaric acids (i.e., six-carbon aldaric acids). Because hexaric acids have four secondary hydroxy groups that are stereochemically diverse and two carboxyl groups, various applications of these acids have been studied. Conventionally, hexaric acids have been produced mainly by nitric acid oxidation of aldohexose, but full-scale commercialization has not been realized; there are many problems regarding yield, safety, environmental burden, etc. In recent years, therefore, improvements in hexaric acid production by nitric acid oxidation have been made, while new production methods, including biocatalytic methods, are actively being studied. In this paper, we summarize these production methods in addition to research on the application of hexaric acids.
糖酸是由醛糖的末端醛基和另一端的羟基氧化为羧基而得到的，称为己二酸（即六碳醛酸）。由于己二酸具有四个立体化学不同的仲羟基和两个羧基，因此对这些酸的各种应用进行了研究。传统上，己二酸主要通过硝酸氧化醛糖来生产，但尚未实现大规模商业化；在产量、安全性、环境负担等方面存在诸多问题。因此，近年来，人们一直在改进硝酸氧化法生产己二酸，同时还积极研究新的生产方法，包括生物催化法。本文除了综述己二酸的应用研究外，还对其生产方法进行了总结。
