Greither Thomas, Marcou Marios, Fornara Paolo, Behre Hermann M
Center for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany.
Clinics for Urology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany.
Cancers (Basel). 2019 Jul 26;11(8):1059. doi: 10.3390/cancers11081059.
Prostate carcinoma (PCa) is one of the leading causes of cancer-related death in males, but biomarkers for the prognosis are rare. Capillary morphogenesis gene 2 (CMG2) is a modulator of extracellular matrix remodeling during angiogenesis. Four isoforms of CMG2 have been described so far, one secreted in the serum as soluble CMG2 (sCMG2). The aim of this study was to evaluate the sCMG2 serum concentrations in 179 PCa patients and 163 age-matched control subjects by ELISA and correlate it to clinical and demographic parameters. We observed that sCMG2 concentration is increased in the serum of PCa patients with metastases, while no significant differences in the concentrations were detected between the control subjects and patients with localized PCa. Furthermore, elevated sCMG2 concentrations were significantly associated with the highest T stage. Increased sCMG2 serum concentrations tended to be associated with a worsened overall and disease-specific survival of the PCa patients. In conclusion, sCMG2 may be an interesting additive biomarker for the prediction of the progression of PCa and the patients' outcome.
前列腺癌（PCa）是男性癌症相关死亡的主要原因之一，但用于预后的生物标志物却很少。毛细血管形态发生基因2（CMG2）是血管生成过程中细胞外基质重塑的调节因子。迄今为止，已描述了CMG2的四种异构体，其中一种以可溶性CMG2（sCMG2）的形式分泌到血清中。本研究的目的是通过酶联免疫吸附测定（ELISA）评估179例PCa患者和163例年龄匹配的对照者血清中sCMG2的浓度，并将其与临床和人口统计学参数相关联。我们观察到，发生转移的PCa患者血清中sCMG2浓度升高，而对照者与局限性PCa患者之间的浓度未检测到显著差异。此外，sCMG2浓度升高与最高的T分期显著相关。sCMG2血清浓度升高往往与PCa患者总体生存率和疾病特异性生存率恶化相关。总之，sCMG2可能是预测PCa进展和患者预后的一个有趣的附加生物标志物。
