葡萄膜黑色素瘤的分子特征：来自癌症基因组图谱（TCGA）项目的见解
Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project.
作者信息
Bakhoum Mathieu F, Esmaeli Bita
机构信息
Shiley Eye Institute, Jacobs Retina Center, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA.
Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Cancers (Basel). 2019 Jul 27;11(8):1061. doi: 10.3390/cancers11081061.
The Cancer Genome Atlas (TCGA) uveal melanoma project was a comprehensive multi-platform deep molecular investigation of 80 uveal melanoma primary tissue samples supported by the National Cancer Institute. In addition to identification of important mutations for the first time, it identified four different clusters (subgroups) of patients paralleling prognosis. The findings of the TCGA marker paper are summarized in this review manuscript and other investigations that have stemmed from the findings of the TCGA project are reviewed.
癌症基因组图谱（TCGA）葡萄膜黑色素瘤项目是一项由美国国立癌症研究所支持的对80份葡萄膜黑色素瘤原发组织样本进行的全面多平台深度分子研究。除了首次鉴定出重要突变外，该项目还识别出了与预后相关的四个不同的患者集群（亚组）。本综述手稿总结了TCGA标志性论文的研究结果，并对源自TCGA项目研究结果的其他调查进行了综述。
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