Avci Mustafa, Kozaci Nalan, Komut Erdal, Komut Seval, Caliskan Gulsum, Tulubas Gul
Department of Emergency Medicine, University of Health Sciences, Antalya Education and Research Hospital, 07100 Antalya, Turkey.
Department of Radiology, Hitit University Medical School, 19040 Corum, Turkey.
Medicina (Kaunas). 2019 Jul 27;55(8):413. doi: 10.3390/medicina55080413.
The optic nerve is a component of the central nervous system, and the optic nerve sheath is connected to the subarachnoid space. For this reason, intracranial pressure (ICP) increases are directly transmitted to the optic nerve sheath. Knowing the normal optic nerve sheath diameter (ONSD) range in a healthy population is necessary to interpret this measurement as a sign of intracranial pressure in clinical practice and research. In this study, we aimed to determine the standard ONSD value in healthy adultsaged65 years of age or older who had not previously been diagnosed with a disease that could increase the ICP.
The right and left ONSD values and ONSD differences were compared, according to the gender of the patients. The patients were divided into 3 groups, according to their age. The age groups were assigned as follows: Group 1: 65-74 years of age; Group 2: 75-84 years of age; and Group 3: 85 years of age or older. The ONSDs and the ONSD difference between the left and right eyes of Group 1, Group 2 and Group 3 were compared.
The study included 195 volunteers. The mean ONSD of both eyes was 4.16±0.69 mm, and the difference between the ONSD of the left and right eyes was 0.16±0.18 mm. There was no difference between genders in terms of right ONSD, left ONSD, mean ONSD and ONSD difference between the left and right eyes. There was no correlation between age and ONSD and ONSD difference. When the age groups and ONSD were compared, no difference was found between the groups.
In conclusion, the ONSDs of both eyes do not vary with age in healthy adults aged65 years or older. ONSD does not vary between genders. The calculation of ONSD difference can be used to determine ICP increase.
视神经是中枢神经系统的一个组成部分，视神经鞘与蛛网膜下腔相连。因此，颅内压（ICP）升高会直接传导至视神经鞘。在临床实践和研究中，将视神经鞘直径（ONSD）测量值解读为颅内压升高的迹象时，了解健康人群的正常ONSD范围很有必要。在本研究中，我们旨在确定65岁及以上未被诊断出患有可能导致颅内压升高疾病的健康成年人的标准ONSD值。
根据患者性别比较左右眼的ONSD值及ONSD差值。根据年龄将患者分为3组。年龄分组如下：第1组：65 - 74岁；第2组：75 - 84岁；第3组：85岁及以上。比较第1组、第2组和第3组左右眼的ONSD及ONSD差值。
该研究纳入了195名志愿者。双眼的平均ONSD为4.16±0.69mm，左右眼ONSD差值为0.16±0.18mm。右眼ONSD、左眼ONSD、平均ONSD以及左右眼ONSD差值在性别方面无差异。年龄与ONSD及ONSD差值之间无相关性。比较年龄组与ONSD时，各年龄组之间未发现差异。
总之，65岁及以上健康成年人双眼的ONSD不会随年龄变化。ONSD在性别之间无差异。ONSD差值的计算可用于确定颅内压升高情况。
