Abuhasira Ran, Zlotnik Yair, Horev Anat, Ifergane Gal
Clinical Research Center, Soroka University Medical Center, Beer Sheva, Israel.
Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.
J Clin Med. 2019 Jul 28;8(8):1118. doi: 10.3390/jcm8081118.
Parkinson's disease (PD) and fibromyalgia (FM) are two relatively common disorders that are considered distinct diagnoses. The aim of this study was to investigate the epidemiological characteristics of patients with both PD and FM, as well as their comorbidities and medication use. We performed a population-based retrospective cohort study in Israel from 2000 to 2015. We identified patients with PD according to a refined medication tracer algorithm and patients with FM according to their medical records. Using the algorithm, we identified 2606 patients diagnosed with PD, 60 of them (2.3%) were also diagnosed with FM. Most of the patients were females (88.3%) and the mean age of FM diagnosis was 63.95 ± 12.27 years. These patients had a higher prevalence of depression, anxiety, and dementia. Of the patients diagnosed with PD + FM, 46 (76.7%) were diagnosed with FM after the diagnosis of PD. Patients with PD + FM used analgesics of distinct kinds in higher rates, as well as more anti-PD medications. We suggest that patients with PD + FM represent a distinct subgroup with a fibromyalgia-like syndrome associated with Parkinson's disease (FLISPAD). Their PD is more treatment resistant, and they take more medications, both analgesics and anti-PD.
帕金森病（PD）和纤维肌痛（FM）是两种相对常见的疾病，被认为是不同的诊断。本研究的目的是调查同时患有PD和FM的患者的流行病学特征，以及他们的合并症和药物使用情况。我们于2000年至2015年在以色列进行了一项基于人群的回顾性队列研究。我们根据一种精确的药物追踪算法识别出PD患者，并根据病历识别出FM患者。通过该算法，我们识别出2606例被诊断为PD的患者，其中60例（2.3%）也被诊断为FM。大多数患者为女性（88.3%），FM诊断的平均年龄为63.95±12.27岁。这些患者患抑郁症、焦虑症和痴呆症的患病率更高。在被诊断为PD+FM的患者中，46例（76.7%）在PD诊断后被诊断为FM。PD+FM患者使用不同种类镇痛药的比例更高，抗PD药物也更多。我们认为，PD+FM患者代表了一个独特的亚组，其患有与帕金森病相关的纤维肌痛样综合征（FLISPAD）。他们的PD更具治疗抵抗性，并且服用更多药物，包括镇痛药和抗PD药物。
