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[新的帕金森病疼痛分类系统(PD-PCS)]

[The new Parkinson's disease pain classification system (PD-PCS)].

作者信息

Mylius V, Perez Lloret S, Brook C S, Krüger M T, Hägele-Link S, Gonzenbach R, Kassubek J, Bohlhalter S, Lefaucheur J P, Timmermann L, Kägi G, Brugger F, Ciampi de Andrade D, Möller J C

机构信息

Klinik für Neurologie und Neurorehabilitation, Kliniken Valens, Valens, Schweiz.

Klinik für Neurologie, Philipps Universität Marburg, Marburg, Deutschland.

出版信息

Nervenarzt. 2022 Oct;93(10):1019-1027. doi: 10.1007/s00115-021-01258-y. Epub 2022 Jan 28.

DOI:10.1007/s00115-021-01258-y
PMID:35089366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9534980/
Abstract

BACKGROUND

Chronic pain is a common non-motor symptom in patients with Parkinson's disease (PD).

AIM

To facilitate the diagnosis of pain in PD, we developed a new classification system the Parkinson's disease pain classification system (PD-PCS) and translated the corresponding validated questionnaire into German.

METHODS

A causal relationship of the respective pain syndrome with PD can be determined by four questions before assigning it hierarchically into one of three pain categories (neuropathic, nociceptive and nociplastic).

RESULTS

In the initial validation study 77% of the patients (122/159) had PD-associated pain comprising 87 (55%) with nociceptive, 36 (22%) with nociplastic and 24 (16%) with neuropathic pain. The study revealed a high validity of the questionnaire and a moderate intrarater and interrater reliability. The questionnaire has been adapted into German and employed in 30 patients.

DISCUSSION

The PD-PCS questionnaire is a valid and reliable tool to determine the relationship of a pain syndrome with PD before classifying it according to the underlying category, facilitating further diagnostics and treatment.

摘要

背景

慢性疼痛是帕金森病(PD)患者常见的非运动症状。

目的

为便于诊断帕金森病患者的疼痛,我们开发了一种新的分类系统——帕金森病疼痛分类系统(PD - PCS),并将相应的经过验证的问卷翻译成德语。

方法

在将各自的疼痛综合征分层归入三种疼痛类别(神经病理性、伤害感受性和神经源性疼痛)之一之前,可通过四个问题确定其与帕金森病的因果关系。

结果

在初始验证研究中,77%的患者(122/159)患有与帕金森病相关的疼痛,其中87例(55%)为伤害感受性疼痛,36例(22%)为神经源性疼痛,24例(16%)为神经病理性疼痛。该研究显示问卷具有较高的效度以及中等程度的评分者内和评分者间信度。该问卷已被翻译成德语并应用于30例患者。

讨论

PD - PCS问卷是一种有效且可靠的工具,可在根据潜在类别对疼痛综合征进行分类之前确定其与帕金森病的关系,便于进一步的诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcaf/9534980/4809e82bf510/115_2021_1258_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcaf/9534980/2ef51a6bf822/115_2021_1258_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcaf/9534980/e3ace60c98bb/115_2021_1258_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcaf/9534980/4809e82bf510/115_2021_1258_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcaf/9534980/2ef51a6bf822/115_2021_1258_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcaf/9534980/e3ace60c98bb/115_2021_1258_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcaf/9534980/4809e82bf510/115_2021_1258_Fig3_HTML.jpg

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Nociplastic pain: towards an understanding of prevalent pain conditions.伤害感受性疼痛:对常见疼痛状况的理解。
Lancet. 2021 May 29;397(10289):2098-2110. doi: 10.1016/S0140-6736(21)00392-5.
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Chronic pain: an update on burden, best practices, and new advances.慢性疼痛:负担、最佳实践和新进展的更新。
Lancet. 2021 May 29;397(10289):2082-2097. doi: 10.1016/S0140-6736(21)00393-7.
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Health-Related Quality of Life for Parkinson's Disease Patients and Their Caregivers.帕金森病患者及其照料者的健康相关生活质量
J Mov Disord. 2021 Jan;14(1):42-52. doi: 10.14802/jmd.20079. Epub 2021 Jan 12.
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J Parkinsons Dis. 2020;10(s1):S37-S48. doi: 10.3233/JPD-202069.
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