Chen Q, Lin L S, Chen L, Lin J, Ding Y, Bao X D, Wu J F, Lin L K, Yan L J, Wang R, Shi B, Qiu Y, Zheng X Y, Pan L Z, Chen F, Wang J, Cai L, He B C, Liu F Q
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Jul 10;40(7):810-814. doi: 10.3760/cma.j.issn.0254-6450.2019.07.015.
To explore the relationship between selenium and the risk for oral cancer. We performed a case-control study in 325 cases of newly diagnosed primary oral cancer from the First Affiliated Hospital of Fujian Medical University and 650 controls from the same hospital and community. Unconditional logistic regression and stratification analyses were used to explore the association between selenium and oral cancer. Adjusted and corresponding 95 were calculated. The analyses on multiple interactions between selenium and smoking or drinking status, and fruit or fish intake frequencies were conducted. The level of serum selenium was 112.42 (80.98-145.06) μg/L in the case group, which was lower than 164.85 (144.44-188.53) μg/L in control group, the difference was statistical significant (<0.01). There was a negative correlation between serum selenium level and the risk for oral cancer regardless of smoking and drinking status, and fruits and fish intake frequencies (<0.05). There were multiple interactions between serum selenium level and smoking or drinking status, and fruit and fish intakes. The high level of serum selenium is a protective factor for the incidence of oral cancer, and serum selenium has multiple interactions with smoking or drinking status, and fruit and fish intakes. Therefore, reducing tobacco use and alcohol consumption and increasing the intakes of fruit and fish can reduce the risk for oral cancer to some extent.
为探究硒与口腔癌风险之间的关系。我们对福建医科大学附属第一医院新诊断的325例原发性口腔癌患者以及来自同一医院和社区的650名对照者进行了一项病例对照研究。采用无条件逻辑回归和分层分析来探究硒与口腔癌之间的关联。计算了调整后的结果及相应的95%置信区间。对硒与吸烟或饮酒状况以及水果或鱼类摄入频率之间的多重交互作用进行了分析。病例组血清硒水平为112.42（80.98 - 145.06）μg/L，低于对照组的164.85（144.44 - 188.53）μg/L，差异具有统计学意义（<0.01）。无论吸烟和饮酒状况以及水果和鱼类摄入频率如何，血清硒水平与口腔癌风险之间均呈负相关（<0.05）。血清硒水平与吸烟或饮酒状况以及水果和鱼类摄入之间存在多重交互作用。血清硒水平高是口腔癌发病的一个保护因素，且血清硒与吸烟或饮酒状况以及水果和鱼类摄入存在多重交互作用。因此，减少烟草使用和酒精消费以及增加水果和鱼类的摄入量可在一定程度上降低口腔癌风险。
