Chen F, He B-C, Yan L-J, Liu F-P, Huang J-F, Hu Z-J, Lin Z, Zheng X-Y, Lin L-S, Zhang Z-F, Cai L
Department of Epidemiology and Health Statistic, School of Public Health, Fujian Medical University, Fuzhou, China.
Department of Stomatology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Eur J Clin Nutr. 2017 Apr;71(4):481-485. doi: 10.1038/ejcn.2016.208. Epub 2017 Feb 8.
BACKGROUND/OBJECTIVES: Epidemiological results on the association between tea consumption and oral cancer remain controversial. We aimed to evaluate the exact relationship between tea consumption and oral cancer in Chinese population.
SUBJECTS/METHODS: A large-scale case-control study was conducted on 586 oral cancer patients and 1024 controls frequency-matched by age and gender. Epidemiological data were collected through face-to-face interviews with a structure questionnaire. Unconditional logistic regression model was used to assess the effect of tea consumption on oral cancer stratified by smoking, alcohol drinking and demographics. Quantity of tea consumed (ml/day) was categorized into five subgroups based on quartiles and then its interactions was evaluated with tobacco smoking and alcohol drinking at each subgroup.
Tea consumption showed an inverse association with oral cancer for non-smokers or non-alcohol drinkers (the odds ratios (ORs) were 0.610 (95% confidence interval (CI): 0.425-0.876) and 0.686 (95% CI: 0.503-0.934), respectively). For smokers or alcohol drinkers, decreased risk was only observed in those who consumed >800 ml/day. Furthermore, oolong tea consumption was associated with decreased risk of oral cancer in smokers or alcohol drinkers but not in non-smokers or non-alcohol drinkers. Tea consumption combined with smoking or/and alcohol drinking had a greater risk than tea consumption alone, but the risk was roughly reduced from zero to Q4 (>800 ml/day). Additionally, when stratified by demographics, the protective effect of tea was especially evident in females, urban residents, normal body mass index population (18.5-23.9), farmers, office workers and those aged <60 years.
Tea consumption protects against oral cancer in non-smokers or non-alcohol drinkers, but this effect may be obscured in smokers or alcohol drinkers. Additionally, demographics may modify the association between tea consumption and oral cancer.
背景/目的：关于饮茶与口腔癌之间关联的流行病学研究结果仍存在争议。我们旨在评估中国人群中饮茶与口腔癌的确切关系。
对象/方法：对586例口腔癌患者和1024例按年龄和性别进行频数匹配的对照者开展了一项大规模病例对照研究。通过采用结构化问卷进行面对面访谈收集流行病学数据。使用无条件逻辑回归模型评估饮茶对口腔癌的影响，并按吸烟、饮酒情况及人口统计学特征进行分层。根据四分位数将每日饮茶量（毫升/天）分为五个亚组，然后在每个亚组中评估其与吸烟和饮酒的交互作用。
对于不吸烟者或不饮酒者，饮茶与口腔癌呈负相关（优势比（OR）分别为0.610（95%置信区间（CI）：0.425 - 0.876）和0.686（95% CI：0.503 - 0.934））。对于吸烟者或饮酒者，仅在每日饮茶量>800毫升的人群中观察到风险降低。此外，饮用乌龙茶与吸烟者或饮酒者口腔癌风险降低相关，但与不吸烟者或不饮酒者无关。饮茶与吸烟或/和饮酒同时存在时的风险高于单独饮茶，但风险大致从最低水平降至第四四分位数（>800毫升/天）时的水平。此外，按人口统计学特征分层时，茶的保护作用在女性、城市居民、正常体重指数人群（18.5 - 23.9）、农民、上班族以及年龄<60岁的人群中尤为明显。
饮茶对不吸烟者或不饮酒者具有预防口腔癌的作用，但在吸烟者或饮酒者中这种作用可能会被掩盖。此外，人口统计学特征可能会改变饮茶与口腔癌之间的关联。
