Faculdade Metropolitana de Camaçari- Jorge Amado, Ponto Certo, Camaçari, BA, 42.801-120, Brazil.
Centro Universitário Estácio da Bahia, Xingu Street, 179 - Stiep, Salvador, BA, Brazil.
Adv Rheumatol. 2019 Jul 29;59(1):34. doi: 10.1186/s42358-019-0074-8.
Systemic lupus erythematosus (SLE) is a multi-systemic, chronic inflammatory disease of autoimmune nature, which can impair performance in daily life activities, causing to a compromised quality of life. Thus, the aim of this study was to evaluate the effect of therapies, such as physical activity, cognitive behavioral therapy, pharmacological treatment and phytotherapy in the quality of life of patients with systemic lupus erythematosus.
A systematic review with a meta-analysis of randomized clinical trials was conducted by searching the PubMed database, including studies comparing patients who participated in cognitive therapy, physical activity, pharmacological treatment or phytotherapeutic treatment.
Of the seven studies included in this meta-analysis, a significant difference was observed in the quality of life of patients with lupus who participated in the intervention groups compared to the control groups (- 10.27 95% CI: - 15, 77 at - 4.77, p = 0.0003, I2 = 0%).
Interventions improve the Quality of life of patients with SLE. However, the methodological quality of the included articles and the sizes of the samples for being small propose that new randomized clinical trials be performed.
系统性红斑狼疮（SLE）是一种多系统、慢性炎症性自身免疫性疾病，可影响日常生活活动能力，导致生活质量下降。因此，本研究旨在评估物理治疗、认知行为疗法、药物治疗和植物疗法等治疗方法对系统性红斑狼疮患者生活质量的影响。
通过检索 PubMed 数据库，对随机临床试验进行系统评价和荟萃分析，纳入比较接受认知治疗、体育活动、药物治疗或植物治疗的患者的研究。
在纳入的 7 项荟萃分析研究中，与对照组相比，接受干预的狼疮患者的生活质量有显著差异（-10.27 95% CI：-15，77 在-4.77，p=0.0003，I2=0%）。
干预措施可改善 SLE 患者的生活质量。然而，由于纳入文章的方法学质量和样本量较小，建议进行新的随机临床试验。
