Lu Ming-Chi, Koo Malcolm
Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 62247, Taiwan.
School of Medicine, Tzu Chi University, Hualien City 97004, Taiwan.
Healthcare (Basel). 2021 Sep 15;9(9):1215. doi: 10.3390/healthcare9091215.
Exercise and physical activity have been deemed as potentially beneficial for patients with systemic lupus erythematosus (SLE). This study aimed to evaluate the effects of exercise interventions on health-related quality of life in patients with SLE using a systematic review and meta-analysis. Randomized and non-randomized controlled trials published up to July 2021 were examined using the PubMed and Embase databases. Of the 1158 articles retrieved, nine were included for systematic review. Five of them were randomized controlled trials and these were assessed using meta-analysis. Hedges' effect size was 0.47; 95% (confidence interval 0.21-0.73; < 0.001) for the physical health and function aspect of health-related quality of life. None of the other seven domains of the SF-36 showed a significant effect size. However, the latter finding was limited by the small number of available trials. In conclusion, this systematic review and meta-analysis supported that exercise intervention compared to usual care might be able to improve the physical functioning domain of health-related quality of life in patients with SLE. Future high-quality randomized controlled trials that incorporate disease-specific health-related quality of life measures are needed to elucidate the role of exercise on health-related quality of life in patients with SLE.
运动和体育活动已被认为对系统性红斑狼疮（SLE）患者可能有益。本研究旨在通过系统评价和荟萃分析评估运动干预对SLE患者健康相关生活质量的影响。使用PubMed和Embase数据库检索截至2021年7月发表的随机和非随机对照试验。在检索到的1158篇文章中，9篇被纳入系统评价。其中5篇为随机对照试验，并使用荟萃分析进行评估。对于健康相关生活质量的身体健康和功能方面，Hedges效应量为0.47；95%置信区间为0.21 - 0.73；P < 0.001。SF - 36的其他七个领域均未显示出显著的效应量。然而，后一发现受到可用试验数量较少的限制。总之，本系统评价和荟萃分析支持，与常规护理相比，运动干预可能能够改善SLE患者健康相关生活质量的身体功能领域。未来需要纳入特定疾病健康相关生活质量测量的高质量随机对照试验，以阐明运动对SLE患者健康相关生活质量的作用。
