Department of Entomology, University of California, Riverside, Riverside, CA 92521, USA.
Department of Entomology, University of California, Riverside, Riverside, CA 92521, USA.
Curr Opin Insect Sci. 2019 Jun;33:7-18. doi: 10.1016/j.cois.2019.01.001. Epub 2019 Jan 14.
Plant virus infection fundamentally alters chemical and behavioral phenotypes of hosts and vectors. These alterations often enhance virus transmission, leading researchers to surmise that such effects are manipulations caused by virus adaptations and not just by-products of pathology. But identification of the virus components behind manipulation is missing from most studies performed to date. Here, we evaluate causative empirical evidence that virus components are the drivers of manipulated host and vector phenotypes. To do so, we link findings and methodologies on virus pathology with observational and functional genomics studies on virus manipulation. Our synthesis provides an overview of progress, areas of synergy, and new approaches that will lead to an improved mechanistic understanding of host and vector manipulation by plant viruses.
植物病毒感染从根本上改变了宿主和媒介的化学和行为表型。这些改变通常会增强病毒的传播，这使得研究人员推测，这些影响是病毒适应的操纵，而不仅仅是病理学的副产品。但迄今为止，大多数研究都没有发现操纵背后的病毒成分。在这里，我们评估了导致宿主和媒介表型被操纵的病毒成分的因果经验证据。为此，我们将病毒病理学的发现和方法与病毒操纵的观察和功能基因组学研究联系起来。我们的综合分析提供了一个概述，展示了进展、协同作用领域以及新方法，这将有助于我们更好地理解植物病毒对宿主和媒介的操纵机制。
