Achilles Jennifer S, Castaneda-Lovato Jennifer
CHRISTUS St. Vincent Regional Medical Center, Santa Fe, New Mexico
CHRISTUS St. Vincent Regional Medical Center, Santa Fe, New Mexico.
Hosp Pediatr. 2019 Aug;9(8):624-631. doi: 10.1542/hpeds.2019-0144.
The incidence of infants born exposed to opioids continues to rise. Historically, newborns with neonatal abstinence syndrome have been treated with medication-weaning protocols, leading to costly and prolonged hospital stays. We aimed to reduce the proportion of newborns with neonatal abstinence syndrome who receive opioid medications for treatment of withdrawal symptoms through a quality improvement program.
In 2016, we formed a multidisciplinary team and used quality improvement methodology to conduct plan-do-study-act cycles. Interventions included prenatal education, family engagement, nonpharmacologic treatments, morphine as needed, and the eat, sleep, console assessment tool. Primary metrics were the proportion of newborns exposed to opioids requiring pharmacologic treatment and the cumulative dose of opioids per exposed newborn requiring pharmacologic treatment.
There were 81 infants in the baseline period (January 2015-September 2016) and 100 infants in the postintervention group (October 2016-August 2018). For infants who required medication for treatment, the postintervention group had significantly lower total cumulative dose in methadone equivalents (1.3 mg vs 6.6 mg), shorter length of stay (10.9 days vs 18.7 days), and nonsignificant lower direct costs ($11 936 vs $15 039).
The described intervention effectively replaced the Finnegan Neonatal Abstinence Scoring System and had improved outcomes in more exposed infants receiving no opioid treatment, and when medication was required, the total cumulative dose of opioids was lower. The postintervention group had shorter average length of stay and lower costs.
暴露于阿片类药物的新生儿出生率持续上升。从历史上看,患有新生儿戒断综合征的新生儿一直采用药物戒断方案进行治疗,导致住院费用高昂且住院时间延长。我们旨在通过一项质量改进计划,降低因新生儿戒断综合征而接受阿片类药物治疗戒断症状的新生儿比例。
2016年,我们组建了一个多学科团队,并使用质量改进方法进行计划-执行-研究-改进循环。干预措施包括产前教育、家庭参与、非药物治疗、按需使用吗啡以及进食、睡眠、安抚评估工具。主要指标是暴露于阿片类药物且需要药物治疗的新生儿比例,以及每个需要药物治疗的暴露新生儿的阿片类药物累积剂量。
基线期(2015年1月至2016年9月)有81名婴儿,干预后组(2016年10月至2018年8月)有100名婴儿。对于需要药物治疗的婴儿,干预后组的美沙酮等效物总累积剂量显著更低(1.3毫克对6.6毫克),住院时间更短(10.9天对18.7天),直接成本降低但无统计学意义(11936美元对15039美元)。
所描述的干预措施有效地取代了芬尼根新生儿戒断评分系统,在更多未接受阿片类药物治疗的暴露婴儿中改善了结局,并且在需要药物治疗时,阿片类药物的总累积剂量更低。干预后组的平均住院时间更短,成本更低。