Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Department of Visceral Surgery and Medicine, Inselspital, University Hospital, University of Bern, Bern, Switzerland.
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.00992-19. Print 2019 Oct.
A pan-susceptible serovar Worthington isolate was detected in the stool of a man returning from Sri Lanka. Under ceftriaxone treatment, a third-generation cephalosporin (3GC)-resistant Worthington was isolated after 8 days. Molecular analyses indicated that the two isolates were identical. However, the latter strain acquired a -carrying IncFII plasmid probably from a isolate colonizing the gut. This is the first report of acquisition of plasmid-mediated resistance to 3GCs in .
从一名从斯里兰卡返回的男子的粪便中检测到了对所有头孢菌素敏感的沃辛顿血清型分离株。在头孢曲松治疗 8 天后,分离出了第三代头孢菌素(3GC)耐药的沃辛顿。分子分析表明两个分离株完全相同。然而,后者菌株可能从定植于肠道的 分离株获得了携带 IncFII 质粒的-。这是首次报道 在 中获得了质粒介导的对 3GCs 的耐药性。