Kepecs Adam
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Cold Spring Harb Symp Quant Biol. 2018;83:219-225. doi: 10.1101/sqb.2018.83.038885. Epub 2019 Jul 29.
The 83rd Cold Spring Harbor Symposium on Quantitative Biology on Brains and Behavior: Order and Disorder in the Nervous System explored the tremendous recent progress in neuroscience and how these advances may be used to improve brain health and address psychiatric and neurological disorders. The Symposium explored a vast array of topics from cell types to cognition. My summary focuses on a few emerging themes. Innovative techniques were ever-present, opening up new experimental possibilities. The commoditization of many state-of-the-art technologies is pushing neuroscience beyond its artisanal ways. Another important theme was "circuits in the middle": Numerous presentations dissected cell type-specific circuits that connect different levels of analysis from molecules to behavior. These new technologies have enabled curiosity-driven investigations in animals to connect more directly with preclinical and clinical studies of human brain disorders. Numerous emerging approaches were presented in human neuroscience, bolstering the hope that circuit-specific manipulations will soon provide improved treatments for brain disorders.
第83届冷泉港定量生物学研讨会聚焦于大脑与行为：神经系统中的秩序与紊乱，探讨了神经科学领域近期取得的巨大进展，以及如何利用这些进展改善大脑健康、应对精神和神经疾病。该研讨会探讨了从细胞类型到认知等一系列广泛的主题。我的总结聚焦于几个新兴主题。创新技术无处不在，开启了新的实验可能性。许多先进技术的商品化正推动神经科学超越其手工方式。另一个重要主题是“中间的回路”：众多报告剖析了细胞类型特异性回路，这些回路连接了从分子到行为的不同分析层面。这些新技术使在动物身上进行的好奇心驱动的研究能够更直接地与人类脑部疾病的临床前和临床研究相联系。人类神经科学领域展示了众多新兴方法，增强了人们的希望，即针对特定回路的操作很快将为脑部疾病提供更好的治疗方法。
