NPU-UoG International Cooperative Lab for Computation and Application in Cardiology, Northwestern Polytechnical University, Xi'an, 710129, China.
Xi'an Key Laboratory of Scientific Computation and Applied Statistics, Northwestern Polytechnical University, Xi'an, 710129, China.
Sci Rep. 2019 Jul 29;9(1):10927. doi: 10.1038/s41598-019-47321-2.
In this paper, a ghost structure (GS) method is proposed to simulate the monodomain model in irregular computational domains using finite difference without regenerating body-fitted grids. In order to verify the validity of the GS method, it is first used to solve the Fitzhugh-Nagumo monodomain model in rectangular and circular regions at different states (the stationary and moving states). Then, the GS method is used to simulate the propagation of the action potential (AP) in transverse and longitudinal sections of a healthy human heart, and with left bundle branch block (LBBB). Finally, we analyze the AP and calcium concentration under healthy and LBBB conditions. Our numerical results show that the GS method can accurately simulate AP propagation with different computational domains either stationary or moving, and we also find that LBBB will cause the left ventricle to contract later than the right ventricle, which in turn affects synchronized contraction of the two ventricles.
本文提出了一种鬼结构（GS）方法，用于在不规则计算域中使用有限差分模拟单域模型，而无需重新生成贴体网格。为了验证 GS 方法的有效性，首先将其用于求解矩形和圆形区域中不同状态（静止和运动状态）的 Fitzhugh-Nagumo 单域模型。然后，使用 GS 方法模拟健康人心的横向和纵向节段中动作电位（AP）的传播，并伴有左束支传导阻滞（LBBB）。最后，我们分析了健康和 LBBB 条件下的 AP 和钙浓度。我们的数值结果表明，GS 方法可以准确地模拟不同计算域中的 AP 传播，无论是静止还是运动的，并且我们还发现 LBBB 会导致左心室比右心室收缩得更晚，这反过来又会影响两个心室的同步收缩。
