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预警评分(NEWS)在脊髓损伤(SCI)人群中特异性差:一项回顾性队列研究。

Poor specificity of National Early Warning Score (NEWS) in spinal cord injuries (SCI) population: a retrospective cohort study.

机构信息

National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, UK.

Oxford Brookes University, Oxford, UK.

出版信息

Spinal Cord. 2020 Feb;58(2):165-173. doi: 10.1038/s41393-019-0330-0. Epub 2019 Jul 29.

DOI:10.1038/s41393-019-0330-0
PMID:31358907
Abstract

STUDY DESIGN

Retrospective chart audit.

OBJECTIVES

The National Early Warning Score (NEWS) is based on seven physiological parameters which can be altered in some individuals with spinal cord injuries (SCI). The aim was to start the development of adapted NEWS suitable for SCI population. The objective was to determine the SBP NEWS specificity based on neurological level of injury (NLI) and completeness of injury.

SETTING

Tertiary centre in the UK.

METHODS

Adult patients admitted for the first time to the National Spinal Injuries Centre between 1 January 2015 and 31 December 2016 were included if they were >6 months post injury. Data were extracted retrospectively including the last ten consecutive BP and heart rate readings before discharge. Data were analysed based on different AIS grades, completeness of injury and NLI.

RESULTS

One hundred and ninety one patients were admitted in 2015 and 2016 and 142 patients were included in the primary analysis. The mean SBP ranged between 92 and 151 mmHg. Patients with the NLI of T6 and above (≥T6) motor complete lesions had a significantly lower SBP than motor incomplete lesions. The specificity of the SBP NEWS was 35.3% in ≥T6 motor complete individuals versus 80.3% in ≥T6 motor incomplete individuals.

CONCLUSION

The baseline BP is significantly lower in the ≥T6 motor complete SCI individuals (>6 months post injury) resulting in a very low specificity of 35.3% to SBP NEWS, which could lead to mismatch between clinical deterioration and NEWS resulting in lack of timely clinical response.

摘要

研究设计

回顾性图表审查。

目的

国家早期预警评分(NEWS)基于七个生理参数,这些参数在某些脊髓损伤(SCI)患者中可能会发生变化。目的是开始开发适合 SCI 人群的适应性 NEWS。目的是根据损伤的神经水平(NLI)和损伤的完整性来确定收缩压 NEWS 的特异性。

设置

英国的一个三级中心。

方法

纳入 2015 年 1 月 1 日至 2016 年 12 月 31 日期间首次入住国家脊髓损伤中心的成年患者,如果他们在受伤后 >6 个月。回顾性提取数据,包括出院前连续 10 次的血压和心率读数。根据不同的 AIS 分级、损伤的完整性和 NLI 进行数据分析。

结果

2015 年和 2016 年共收治 191 例患者,142 例患者纳入主要分析。平均收缩压范围在 92 至 151mmHg 之间。NLI 为 T6 及以上(≥T6)的运动完全性损伤患者的收缩压明显低于运动不完全性损伤患者。收缩压 NEWS 的特异性在≥T6 运动完全性个体中为 35.3%,而在≥T6 运动不完全性个体中为 80.3%。

结论

≥T6 运动完全性 SCI 个体(>6 个月)的基础血压明显较低,导致收缩压 NEWS 的特异性非常低(35.3%),这可能导致临床恶化与 NEWS 之间不匹配,导致缺乏及时的临床反应。

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Loss of circadian blood pressure variability in complete tetraplegia.完全性四肢瘫痪患者昼夜血压变异性丧失。
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