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1
Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease.开放性、多中心、剂量递增的Ⅱ期临床试验，评估替德西利单抗（IL-18BP）治疗成人斯蒂尔病的安全性和疗效。
Ann Rheum Dis. 2018 Jun;77(6):840-847. doi: 10.1136/annrheumdis-2017-212608. Epub 2018 Feb 22.
2
Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.白细胞介素-18 在诊断上区分并促进人类和鼠类的巨噬细胞活化综合征的发病机制。
Blood. 2018 Mar 29;131(13):1442-1455. doi: 10.1182/blood-2017-12-820852. Epub 2018 Jan 11.
3
Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice.IL-18 信号无拮抗导致小鼠 TLR9 诱导的巨噬细胞活化综合征加重。
Blood. 2018 Mar 29;131(13):1430-1441. doi: 10.1182/blood-2017-06-789552. Epub 2018 Jan 2.
4
Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.致命性 NLRC4 相关过度炎症经 IL-18 抑制治疗成功。
J Allergy Clin Immunol. 2017 May;139(5):1698-1701. doi: 10.1016/j.jaci.2016.10.022. Epub 2016 Nov 19.
5
Elevated serum levels of free interleukin-18 in adult-onset Still's disease.成人斯蒂尔病患者血清游离白细胞介素-18水平升高。
Rheumatology (Oxford). 2016 Dec;55(12):2237-2247. doi: 10.1093/rheumatology/kew300. Epub 2016 Sep 10.
6
Pathogenesis of macrophage activation syndrome and potential for cytokine- directed therapies.巨噬细胞活化综合征的发病机制及细胞因子导向治疗的潜力。
Annu Rev Med. 2015;66:145-59. doi: 10.1146/annurev-med-061813-012806. Epub 2014 Nov 5.
7
Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles.基于细胞因子谱的系统性幼年特发性关节炎患者的不同亚群。
Cytokine. 2013 Feb;61(2):345-8. doi: 10.1016/j.cyto.2012.11.025. Epub 2012 Dec 29.
8
High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein.在存在高浓度白细胞介素-18 结合蛋白的情况下，活动期系统性红斑狼疮患者循环中白细胞介素-18 水平升高。
J Autoimmun. 2010 Mar;34(2):121-6. doi: 10.1016/j.jaut.2009.08.002. Epub 2009 Aug 22.

IL-18 as therapeutic target in a patient with resistant systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome.

作者信息

Yasin Shima, Solomon Krista, Canna Scott W, Girard-Guyonvarc'h Charlotte, Gabay Cem, Schiffrin Eduardo, Sleight Andrew, Grom Alexei A, Schulert Grant S

机构信息

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

Pediatric Rheumatology & Immunology, Children's Hospital of Pittsburgh/UPMC, Pittsburgh, PA, USA.

出版信息

Rheumatology (Oxford). 2020 Feb 1;59(2):442-445. doi: 10.1093/rheumatology/kez284.

DOI:10.1093/rheumatology/kez284
PMID:31359055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8453620/
Abstract
摘要