Institute of Veterinary Immunology &Engineering, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing, 210014, China.
Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, Yangzhou, 225009, China.
Appl Microbiol Biotechnol. 2019 Sep;103(18):7317-7324. doi: 10.1007/s00253-019-10014-x. Epub 2019 Jul 29.
Long polar fimbria (LPF) is one of the few fimbrial adhesins of enterohemorrhagic Escherichia coli (E. coli) O157:H7 associated with colonization on host intestine, and both two types of LPF (including LPF1 and LPF2) play essential roles during the bacterial infection process. Though the fimbriae had been well studied in intestinal pathogenic E. coli strains, new evidences from our research revealed that it might be the key virulence for bovine mastitis pathogenic E. coli (MPEC) as well. This article summarizes the current knowledge on the LPF in E. coli, focusing on its genetic characteristics, prevalence, expression regulation, and adherence mechanism in different pathotypes of E. coli strains.
长极性菌毛（LPF）是肠出血性大肠杆菌（E. coli）O157:H7 与宿主肠道定植相关的少数菌毛黏附素之一，两种类型的 LPF（包括 LPF1 和 LPF2）在细菌感染过程中都发挥着重要作用。尽管菌毛在肠道致病性大肠杆菌菌株中已经得到了很好的研究，但我们的研究新发现表明，它也可能是牛乳腺炎致病性大肠杆菌（MPEC）的关键毒力因子。本文总结了大肠杆菌中 LPF 的最新研究进展，重点介绍了其在不同大肠杆菌菌株的不同病原型中的遗传特征、流行情况、表达调控和黏附机制。
