Department of Radiation Oncology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, 39216, USA.
Department of Radiation Oncology, John Theurer Cancer Center, an HMH-MSKCC partnership, 92 2nd St, Hackensack, NJ, 07601, USA.
Curr Oncol Rep. 2019 Jul 29;21(9):79. doi: 10.1007/s11912-019-0828-9.
The incidence of non-melanomatous skin cancer (NMSC) increases with age and there are specific considerations regarding management of NMSC for the older patient population. Here we will review current data regarding treatment considerations and options for older patients with NMSC.
Hypofractionated regimens and high-dose brachytherapy may be non-surgical treatment options for older patients with NMSC. Other less aggressive strategies such as active surveillance can also be considered in some settings. Management of NMSC in the older patient population requires a thorough assessment of comorbidities, frailty, and life expectancy. Additionally, discussions regarding goals of care and quality of life (QOL) issues are especially important in this population. Older patients with NMSC in particular may benefit from a tailored treatment plan based on current available data rather than a broad application of general treatment guidelines for NMSC.
非黑素瘤皮肤癌（NMSC）的发病率随年龄增长而增加，老年患者人群在 NMSC 的管理方面有一些特殊的考虑因素。在此，我们将回顾目前关于老年 NMSC 患者的治疗考虑因素和选择的相关数据。
对于老年 NMSC 患者，分割剂量方案和高剂量近距离放射治疗可能是一种非手术治疗选择。在某些情况下，其他侵袭性较小的策略，如主动监测，也可以考虑。老年患者人群中 NMSC 的管理需要对合并症、虚弱和预期寿命进行全面评估。此外，在该人群中，特别要讨论护理目标和生活质量（QOL）问题。患有 NMSC 的老年患者可能受益于基于现有数据的个体化治疗计划，而不是广泛应用 NMSC 的一般治疗指南。
