神经肽前体加工过程中羧肽酶H的抑制性和刺激性调控机制
Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing.
作者信息
Hook V Y
机构信息
Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
出版信息
Cell Mol Neurobiol. 1988 Mar;8(1):49-55. doi: 10.1007/BF00712911.
Abstract
- Carboxypeptidase H is one of several proteolytic processing enzymes required for conversion of large neuropeptide precursors into the small peptide neurotransmitters and hormones. 2. Because of the importance of posttranslational processing as a regulatory step for the production of active peptides, recent studies investigating control mechanisms for carboxypeptidase H (CPH) are reviewed. 3. Evidence is discussed which illustrates how CPH can be inhibited and activated. These findings suggest that a processing enzyme can play a role in the control of neuropeptide production. 4. It will be important in further studies to understand how the multiple processing enzymes--endopeptidase(s) and aminopeptidase, along with CPH--are coordinately regulated for the synthesis of active peptides.
摘要
- 羧肽酶H是将大的神经肽前体转化为小的肽类神经递质和激素所需的几种蛋白水解加工酶之一。2. 由于翻译后加工作为活性肽产生的调控步骤至关重要，本文综述了最近关于羧肽酶H（CPH）调控机制的研究。3. 讨论了表明CPH如何被抑制和激活的证据。这些发现表明一种加工酶可在神经肽产生的控制中发挥作用。4. 在进一步的研究中，了解多种加工酶——内肽酶和氨肽酶以及CPH——如何协同调控以合成活性肽将非常重要。
相似文献
1
Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing.神经肽前体加工过程中羧肽酶H的抑制性和刺激性调控机制
Cell Mol Neurobiol. 1988 Mar;8(1):49-55. doi: 10.1007/BF00712911.
2
Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?
Life Sci. 1982;31(16-17):1793-6. doi: 10.1016/0024-3205(82)90212-0.
3
Product inhibition of carboxypeptidase H.羧肽酶H的产物抑制作用。
J Biol Chem. 1987 Sep 15;262(26):12583-8.
4
A carboxypeptidase processing enzyme for enkephalin precursors.一种用于脑啡肽前体的羧肽酶加工酶。
Nature. 1982 Jan 28;295(5847):341-2. doi: 10.1038/295341a0.
5
Processing of prodynorphin in BRL-3A cells, a rat liver-derived cell line: implications for the specificity of neuropeptide-processing enzymes.
Mol Cell Endocrinol. 1993 Jul;94(1):37-45. doi: 10.1016/0303-7207(93)90049-p.
6
Identification of zymogen and mature forms of human carboxypeptidase H. A processing enzyme for the synthesis of peptide hormones.人羧肽酶H的酶原形式和成熟形式的鉴定。一种用于肽激素合成的加工酶。
FEBS Lett. 1988 Oct 10;238(2):338-42. doi: 10.1016/0014-5793(88)80508-8.
7
Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules.脑啡肽转换酶：一种定位于肾上腺嗜铬颗粒的特异性脑啡肽合成羧肽酶的纯化及特性研究
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3886-90. doi: 10.1073/pnas.79.12.3886.
8
Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase H, a prohormone processing enzyme.精氨酸和赖氨酸对牛肾上腺髓质羧肽酶H（一种激素原加工酶）的产物抑制作用。
Life Sci. 1990;47(13):1135-9. doi: 10.1016/0024-3205(90)90173-o.
9
Carboxypeptidase B-like activity for the processing of enkephalin precursors in the membrane component of bovine adrenomedullary chromaffin granules.牛肾上腺髓质嗜铬颗粒膜成分中用于脑啡肽前体加工的羧肽酶B样活性。
Neuropeptides. 1984 Mar;4(2):117-26. doi: 10.1016/0143-4179(84)90122-7.
10
Primary structure and tissue distribution of anglerfish carboxypeptidase H.安康鱼羧肽酶H的一级结构和组织分布
Mol Cell Endocrinol. 1991 Jul;78(3):171-8. doi: 10.1016/0303-7207(91)90120-h.
引用本文的文献
1
Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus.羧肽酶D：一种在红斑狼疮患者中失调的新型转化生长因子β靶基因。
J Clin Immunol. 2007 Nov;27(6):568-79. doi: 10.1007/s10875-007-9118-7. Epub 2007 Jul 20.
本文引用的文献
1
Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA.人甲硫氨酸脑啡肽和亮氨酸脑啡肽前体及其信使核糖核酸的一级结构。
Nature. 1982 Feb 25;295(5851):663-6. doi: 10.1038/295663a0.
2
A carboxypeptidase processing enzyme for enkephalin precursors.一种用于脑啡肽前体的羧肽酶加工酶。
Nature. 1982 Jan 28;295(5847):341-2. doi: 10.1038/295341a0.
3
Post-translational proteolysis in polypeptide hormone biosynthesis.多肽激素生物合成中的翻译后蛋白水解作用。
Annu Rev Physiol. 1982;44:625-38. doi: 10.1146/annurev.ph.44.030182.003205.
4
Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules.脑啡肽转换酶：一种定位于肾上腺嗜铬颗粒的特异性脑啡肽合成羧肽酶的纯化及特性研究
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3886-90. doi: 10.1073/pnas.79.12.3886.
5
A sensitive radiometric assay for enkephalin convertase and other carboxypeptidase B-like enzymes.一种用于脑啡肽转换酶及其他类羧肽酶B样酶的灵敏放射分析方法。
Life Sci. 1984 Jan 9;34(2):113-21. doi: 10.1016/0024-3205(84)90581-2.
6
Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase.脑啡肽合成羧肽酶——脑啡肽转换酶的纯化与特性分析
J Biol Chem. 1983 Sep 25;258(18):10950-5.
7
Alternative modes of enkephalin biosynthesis regulation by reserpine and cyclic AMP in cultured chromaffin cells.利血平和环磷酸腺苷对培养的嗜铬细胞中脑啡肽生物合成调节的其他模式。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):3949-53. doi: 10.1073/pnas.81.13.3949.
8
Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary.大鼠垂体分泌颗粒中的羧肽酶B样转换酶活性
Proc Natl Acad Sci U S A. 1984 May;81(9):2776-80. doi: 10.1073/pnas.81.9.2776.
9
Regulation of the adrenal medulla.肾上腺髓质的调节
Physiol Rev. 1983 Jul;63(3):787-843. doi: 10.1152/physrev.1983.63.3.787.
10
Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin.牛肾上腺前脑啡肽原cDNA的克隆与序列分析
Nature. 1982 Jan 21;295(5846):202-6. doi: 10.1038/295202a0.
Zotero 插件