Noda M, Furutani Y, Takahashi H, Toyosato M, Hirose T, Inayama S, Nakanishi S, Numa S
Nature. 1982 Jan 21;295(5846):202-6. doi: 10.1038/295202a0.
The nucleotide sequence of cloned cDNA for preproenkephalin from bovine adrenal medulla indicates that the precursor protein contains four copies of Met-enkephalin and one copy each of Leu-enkephalin, Met-enkephalin-Arg6-Phe7 and Met-enkephalin-Arg6-Gly7-Leu8, a previously undetected opioid peptide. The enkephalin and extended enkephalin sequences are each bounded by paired basic amino acid residues. Preproenkephalin may represent a multi-hormone precursor, like the corticotropin-beta-lipotropin precursor.
来自牛肾上腺髓质的前脑啡肽原克隆cDNA的核苷酸序列表明，前体蛋白包含四个甲硫氨酸脑啡肽拷贝、一个亮氨酸脑啡肽拷贝、一个甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7拷贝和一个甲硫氨酸脑啡肽-精氨酸6-甘氨酸7-亮氨酸8拷贝，后者是一种以前未检测到的阿片肽。脑啡肽和延伸脑啡肽序列均由成对的碱性氨基酸残基界定。前脑啡肽原可能代表一种多激素前体，类似于促肾上腺皮质激素-β-促脂素前体。
