Center for Cerebrovascular Research, Department of Anesthesia and Perioperative care, University of California, San Francisco, California.
Department of Neurological Surgery, University of California, San Francisco, California.
CNS Neurosci Ther. 2019 Oct;25(10):1085-1095. doi: 10.1111/cns.13200. Epub 2019 Jul 29.
Patients with brain arteriovenous malformation (bAVM) are at risk of intracranial hemorrhage (ICH). Overall, bAVM accounts for 25% of hemorrhagic strokes in adults <50 years of age. The treatment of unruptured bAVMs has become controversial, because the natural history of these patients may be less morbid than invasive therapies. Available treatments include observation, surgical resection, endovascular embolization, stereotactic radiosurgery, or combination thereof. Knowing the risk factors for bAVM hemorrhage is crucial for selecting appropriate therapeutic strategies. In this review, we discussed several biological risk factors, which may contribute to bAVM hemorrhage.
脑动静脉畸形（bAVM）患者有发生颅内出血（ICH）的风险。总体而言，bAVM 占 50 岁以下成人出血性中风的 25%。未破裂 bAVM 的治疗已成为争议的焦点，因为这些患者的自然病程可能不如侵袭性治疗那样严重。可选择的治疗方法包括观察、手术切除、血管内栓塞、立体定向放射外科或联合治疗。了解 bAVM 出血的危险因素对于选择合适的治疗策略至关重要。在这篇综述中，我们讨论了几个可能导致 bAVM 出血的生物学危险因素。
