Mishra Vikash Chandra, Tiwari Aseem K, Dorwal Pranav, Raina Vimarsh, Sharma Girish
Chimera Transplant Research Foundation, New Delhi, India.
GeneBandhu, New Delhi, India.
Asian J Transfus Sci. 2019 Jan-Jun;13(1):39-42. doi: 10.4103/ajts.AJTS_145_18.
Hematopoietic progenitor cell transplantation (HPCT) is used as a definitive treatment in hematological malignancies. For a successful HPCT, the donor and recipient should have matching human leukocyte antigens (HLAs). About 25% of patients have a chance of finding matching HLA within family, while rests 75% are dependent on voluntary stem cell donor. Globally, there are 75 stem cell registries with more than 30 million donors registered among which India represents 0.36 million. Therefore, finding a stem cell donor for Indian patient is quite difficult. The aim of the present study is to discuss the significance of voluntary stem cell donor recruitment drive and also to guide the drive organizers and their team for effectively organizing the drive to increase the database of such donors.
Voluntary stem cell donor recruitment drives are conducted to spread awareness among the people and motivate them to register as a donor. Once the donors have given their consent, the sample is taken and sent to laboratory for HLA typing and the result is uploaded in World Marrow Donor Association, an international association of member to find the best possible matches for patients with hematological disorders.
Genebandhu has organized over 127 recruitment camps since 2012 and recruited 13,000 voluntary stem cell donors. HLA typing of 7446 donors has been completed. Out of this small number of typed donors, 11 lifesaving HPCTs have been successfully facilitated.
Here, we have demonstrated guidelines along with steps to organize voluntary stem cell donors recruitment drive that is needed to increase number of donors, thus increasing significantly the chances of saving many vital lives.
造血祖细胞移植（HPCT）被用作血液系统恶性肿瘤的确定性治疗方法。为了成功进行HPCT，供体和受体的人类白细胞抗原（HLA）应相匹配。约25%的患者有机会在家族中找到匹配的HLA，而其余75%则依赖自愿干细胞供体。在全球范围内，有75个干细胞登记处，登记的供体超过3000万，其中印度有36万。因此，为印度患者找到干细胞供体相当困难。本研究的目的是讨论自愿干细胞供体招募活动的意义，并指导活动组织者及其团队有效组织活动，以增加此类供体的数据库。
开展自愿干细胞供体招募活动，以提高人们的认识并激励他们登记成为供体。一旦供体给予同意，采集样本并送往实验室进行HLA分型，结果上传至世界骨髓捐献者协会，该协会是一个国际会员协会，旨在为血液系统疾病患者寻找最佳匹配供体。
自2012年以来，Genebandhu组织了127多个招募营地，招募了13000名自愿干细胞供体。已完成7446名供体的HLA分型。在这一小部分已分型的供体中，已成功促成11例挽救生命的HPCT。
在此，我们展示了组织自愿干细胞供体招募活动的指导方针及步骤，这对于增加供体数量是必要的，从而显著增加挽救许多重要生命的机会。
