Hurley C K, Maiers M, Marsh S G E, Oudshoorn M
Georgetown University, Washington, DC 20057, USA.
Tissue Antigens. 2007 Apr;69 Suppl 1:3-5. doi: 10.1111/j.1399-0039.2006.758_2.x.
Over 10 million volunteer donors and cord blood units are typed for human leukocyte antigen (HLA) within hematopoietic stem cell registries and cord blood banks. Identification of matched donors in countries different from that of the searching patient is facilitated by Bone Marrow Donors Worldwide and the World Marrow Donor Association (WMDA). A survey of new volunteer donor typing among WMDA member registries has identified the methods and resolution of HLA testing and the level of quality control used to evaluate the accuracy of typing results. The diversity of HLA assignments within registries has generated a number of informatics challenges. Registries are using population genetics to enhance registry diversity and to facilitate the identification of matched donors.
在造血干细胞登记处和脐带血库中，超过1000万志愿捐献者和脐带血样本进行了人类白细胞抗原（HLA）分型。全球骨髓捐献者组织和世界骨髓捐献者协会（WMDA）推动了在与搜索患者所在国家不同的国家中识别匹配捐献者的工作。一项对WMDA成员登记处新志愿捐献者分型的调查确定了HLA检测的方法和分辨率以及用于评估分型结果准确性的质量控制水平。登记处内HLA分配的多样性带来了一些信息学挑战。登记处正在利用群体遗传学来提高登记处的多样性，并便于识别匹配的捐献者。
