Inflammatory Lung Diseases Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran.
Int J Chron Obstruct Pulmon Dis. 2019 Jul 8;14:1495-1501. doi: 10.2147/COPD.S207400. eCollection 2019.
COPD is an irreversible chronic illness with airflow limitation. The aim of the current study was to assess the role of vitamin D on quality of life and pulmonary function in patients with COPD. A randomized, double-blinded clinical trial was conducted in 63 patients with COPD. Patients were placed into intervention and placebo groups. Each individual in the intervention group took 50,000 IU vitamin Donce a week for 8 weeks and then once a month for 4 months. There was no significant difference among FEV, FEV/FVC, and number of exacerbations in patients with COPD (>0.05). In the intervention group, a significant difference was observed in quality of life at 2 months (<0.001) and 6 months (<0.001). In addition, qualitative analysis showed that the status of exacerbation had not got worse six months after initiation in the intervention group. The current study shows that consumption of 50,000 IU vitamin D, as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.
COPD 是一种不可逆的慢性疾病，伴有气流受限。本研究的目的是评估维生素 D 对 COPD 患者生活质量和肺功能的影响。对 63 名 COPD 患者进行了一项随机、双盲临床试验。患者被分为干预组和安慰剂组。干预组的每个人每周服用 50000IU 维生素 D 一次，持续 8 周，然后每月一次，持续 4 个月。FEV、FEV/FVC 和 COPD 患者的恶化次数之间没有显著差异（>0.05）。在干预组中，生活质量在 2 个月（<0.001）和 6 个月（<0.001）时差异显著。此外，定性分析表明，在干预组开始治疗 6 个月后，恶化状况没有恶化。本研究表明，摄入 50000IU 维生素 D，作为日常饮食中的一种方便补充，能够提高 COPD 患者的生活质量。
