Menezes Paula Dos Passos, Gomes Cristiane Vilaça Campos, de Carvalho Yasmim Maria Barbosa Gomes, Santos Nayara Gomes Lima, Andrade Valléria Matos, Oliveira Ana Maria Santos, de Lima Cláudio Moreira, Araújo Adriano Antunes de Souza
Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Brazil.
Department of Medicine, Federal University of Sergipe, São Cristóvão, Brazil.
Clin Med Insights Case Rep. 2019 Jul 18;12:1179547619858977. doi: 10.1177/1179547619858977. eCollection 2019.
Venous ulcers are a more severe complication of chronic venous insufficiency, significantly compromising patient quality of life (QoL). Compressive stockings are still the gold standard treatment method with alternative therapies currently being evaluated. In this perspective, we investigate the influence of compressive stockings impregnated with hesperetin-based nanocapsules in the healing process of venous ulcers. Compressive stockings impregnated with hesperetin-based nanocapsules were applied to a consenting patient for 6 months following all relevant ethical principles for patient studies. The patient was evaluated at baseline (T0), 3 months (T3), and 6 months (T6), using photographic register (healing) probes to measure skin melanin, erythema and hydration parameters, and venous diameters, followed by questionnaires regarding QoL and pain perception. Healing was observed at the 3-month time point and with 91.6% and 93.1% of retraction area in larger ulcers of the right leg and lateral portion of the left leg, respectively. The deepest ulcer in a medial portion of the left leg healed 47.3%. A reduction of all measured skin parameters was observed, indicating a possible hesperetin effect. The scores of QoL and pain were, respectively, in the ranges of 91.6 to 31.2 and 7 to 0. Reduction in venous diameters also indicates healing function. These preliminary findings suggest that compressive stockings impregnated with hesperetin nanocapsules enhance venous ulcer healing. Further clinical trial controlled by placebo, involving a greater number of patients, is required to confirm the findings of this case report.
静脉性溃疡是慢性静脉功能不全更为严重的并发症，会显著影响患者的生活质量（QoL）。压力袜仍是金标准治疗方法，目前正在评估替代疗法。从这个角度来看，我们研究了含有橙皮素纳米胶囊的压力袜对静脉性溃疡愈合过程的影响。按照所有相关的患者研究伦理原则，将含有橙皮素纳米胶囊的压力袜应用于一名同意参与的患者，为期6个月。在基线（T0）、3个月（T3）和6个月（T6）时对患者进行评估，使用摄影记录（愈合情况）探头测量皮肤黑色素、红斑和水合参数以及静脉直径，随后进行关于生活质量和疼痛感知的问卷调查。在3个月时间点观察到愈合情况，右腿较大溃疡和左腿外侧部分溃疡的回缩面积分别为91.6%和93.1%。左腿内侧最深的溃疡愈合了47.3%。观察到所有测量的皮肤参数均有所降低，表明可能存在橙皮素的作用。生活质量和疼痛评分分别在91.6至31.2以及7至0的范围内。静脉直径的减小也表明具有愈合功能。这些初步研究结果表明，含有橙皮素纳米胶囊的压力袜可促进静脉性溃疡的愈合。需要通过安慰剂对照的进一步临床试验，纳入更多患者，以证实本病例报告的研究结果。
