一种无脊椎动物烟碱型乙酰胆碱受体基因的特性：果蝇的ard基因
Characterization of an invertebrate nicotinic acetylcholine receptor gene: the ard gene of Drosophila melanogaster.
作者信息
Sawruk E, Hermans-Borgmeyer I, Betz H, Gundelfinger E D
机构信息
ZMBH, Universität Heidelberg, FRG.
出版信息
FEBS Lett. 1988 Aug 1;235(1-2):40-6. doi: 10.1016/0014-5793(88)81230-4.
The ard gene encodes a neuronal nicotinic acetylcholine receptor (AChR) protein from Drosophila (ARD protein). Cytogenetically this gene maps at position 64B/C on the left arm of the 3rd chromosome. Five introns interrupt the protein coding region of the gene, and one is found upstream of the translation start site. The ard gene thus contains less introns than vertebrate muscle AChR genes, but, with one exception, the positions of the resident introns are precisely conserved. Implications for the evolution of AChR genes are discussed.
ard基因编码来自果蝇的一种神经元烟碱型乙酰胆碱受体（AChR）蛋白（ARD蛋白）。从细胞遗传学角度看，该基因定位于第3号染色体左臂的64B/C位置。五个内含子中断了该基因的蛋白质编码区，且在翻译起始位点上游发现了一个内含子。因此，ard基因所含的内含子比脊椎动物肌肉AChR基因少，但除了一个例外，所含内含子的位置精确保守。文中讨论了对AChR基因进化的影响。
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