通过治疗药物监测成功确定慢性髓性白血病合并肝功能不全患者的尼洛替尼剂量：一例报告。
Successful determination of nilotinib dosage by therapeutic drug monitoring in a patient with chronic myeloid leukemia developing hepatic dysfunction: A case report.
作者信息
Nakahara Ryosuke, Sumimoto Takahiro, Ogata Masao, Sato Yuhki, Itoh Hiroki
机构信息
Department of Clinical Pharmacy Oita University Hospital Yufu-shi Japan.
Department of Hematology Oita University Hospital Yufu-shi Japan.
出版信息
Clin Case Rep. 2019 Jun 14;7(7):1419-1421. doi: 10.1002/ccr3.2191. eCollection 2019 Jul.
Abstract
Fixed dosage regimen is currently the standard therapy with tyrosine kinase inhibitors (TKI). This case report demonstrates successful determination of nilotinib dosage by therapeutic drug monitoring (TDM) in a patient with chronic myeloid leukemia (CML). TDM may provide useful marker for individualized dosing of TKI for the treatment of CML.
摘要
固定剂量方案目前是酪氨酸激酶抑制剂（TKI）的标准疗法。本病例报告展示了通过治疗药物监测（TDM）成功确定一名慢性粒细胞白血病（CML）患者的尼罗替尼剂量。TDM可为TKI治疗CML的个体化给药提供有用的指标。
Zotero 插件